Raymond Andersen

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Raymond Andersen

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Research and Teaching Interests

The research interests of Dr. Andersen's group involve the isolation and structure elucidation of novel organic metabolites produced by marine organisms. Biosynthetic studies are carried out on the novel metabolites when it is feasible. The structures of the new metabolites are elucidated primarily by spectroscopic analysis. Multipulse 1D and 2D nmr experiments play a pivotal role in the structure elucidation. As a rule, the molecules investigated have to meet one or more of the following criteria: i) they should be of theoretical interest due to the novelty of their biogenesis - for example terpenes with new carbon skeletons, ii) they should display in vitro biological activity which makes them potential leads for the development of pharmaceutical agents and/or iii) they should display biological activities that allow them to play a central role in the biology of the producing organism (i.e. chemical ecology). Some current projects are described below.

Marine invertebrates and bacteria are cont inually collected from tropical and cold temperate ocean habitats and their extracts are screened for novel cytotoxic secondary metabolites that are potential leads for the development of new anticancer drugs. Marine bacteria are being examined as a source of novel antibiotics that are active against 'antibiotic resistant' human pathogens. Marine invertebrate and microbial extracts are being examined as a source of i) novel protein phosphatase and protein kinase inhibitors, ii) novel antimitotic agents, and iii) new cell cycle check point inhibitors.

Dorid nudibranchs are delicate, shell-less and often highly colored molluscs that are apparently ill equipped to ward off predators. The defensive metabolites found in the skin extracts of nudibranchs are being studied. Recent efforts have been focused on using stable isotope methodology to study the de novo biosynthesis of terpenoid and polyketide metabolites by dorid nudibranchs.

 

Madangamine A, a cytotoxic pentacyclcic alkaloid isolated from the sponge Xestospongia ingens

 

Contact

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Office Room Number(s): 
COPP Building 4207
Office Phone Number: 
604-822-4511
Fax Number: 
604-822-2847

Curriculum Vitae

B.Sc., Alberta (1969); M.Sc., Berkeley (1970); Ph.D., California at San Diego (D.J. Faulkner, 1975); Postdoctoral, M.I.T., (G. Büchi 1975-76); Chemical Institute of Canada - Merck Sharpe and Dohme Lecture Award (1987), Royal Society of Canada - Rutherford Medal in Chemistry (1988); UBC Killam Research Prize (1987); Fellow of the Chemical Institute of Canada (1987); UBC Killam Faculty Research Fellowship (1993); Fellow of the Royal Society of Canada (2000); Arthur E. Schwarting Award, American Society of Pharmacognosy (2003); Killam Graduate Teaching Prize, UBC (2005); R.U.Lemieux Award, CSC (2009); Jacob Biely Research Prize, UBC (2011); Paul J. Scheuer Award (2012); CIC Medal (2012)

Publications

2013

Du, Y. - L. ; Dalisay, D. S. ; Andersen, R. J. ; Ryan, K. S. N-Carbamoylation Of 2,4-Diaminobutyrate Reroutes The Outcome In Padanamide Biosynthesis. Chemistry & Biology 2013, 20, 1002-1011.

2010

Daoust, J. ; Fontana, A. ; Merchant, C. E. ; de Voogd, N. J. ; Patrick, B. O. ; Kieffer, T. J. ; Andersen, R. J. Ansellone A, A Sesterterpenoid Isolated From The Nudibranch Cadlina Luteromarginata And The Sponge Phorbas Sp., Activates The Camp Signaling Pathway. Organic Letters 2010, 12, 3208 - 3211.
Williams, D. E. ; Amlani, A. ; Dewi, A. S. ; Patrick, B. O. ; van Ofwegen, L. ; Mui, A. L. - F. ; Andersen, R. J. Australin E Isolated From The Soft Coral Cladiella Sp. Collected In Pohnpei Activates The Inositol 5-Phosphatase Ship1. Australian Journal of Chemistry 2010, 63, 895 - 900.
Carr, G. ; Williams, D. E. ; Diaz-Marrero, A. R. ; Patrick, B. O. ; Bottriell, H. ; Balgi, A. D. ; Donohue, E. ; Roberge, M. ; Andersen, R. J. Bafilomycins Produced In Culture By Streptomyces Spp. Isolated From Marine Habitats Are Potent Inhibitors Of Autophagy. Journal of Natural Products 2010, 73, 422 - 427.
Meimetis, L. G. ; Nodwell, M. ; Wang, C. ; Yang, L. ; Mui, A. L. ; Ong, C. ; Krystal, G. ; Andersen, R. J. Development Of Ship Activators: Potentially Selective Cancer Therapy. In; American Chemical Society, 2010; p. ORGN-936.
Andersen, R. J. ; Mawji, N. R. ; Wang, J. ; Wang, G. ; Haile, S. ; Myung, J. - K. ; Watt, K. ; Tam, T. ; Yang, Y. Chi; Banuelos, C. A. ; Williams, D. E. ; McEwan, I. J. ; Wang, Y. ; Sadar, M. D. Regression Of Castrate-Recurrent Prostate Cancer By A Small-Molecule Inhibitor Of The Amino-Terminus Domain Of The Androgen Receptor. Cancer cell 2010, 17, 535 - 46.
Pereira, A. R. ; Strangman, W. K. ; Marion, F. ; Feldberg, L. ; Roll, D. ; Mallon, R. ; Hollander, I. ; Andersen, R. J. Synthesis Of Phosphatidylinositol 3-Kinase (Pi3K) Inhibitory Analogues Of The Sponge Meroterpenoid Liphagal. Journal of Medicinal Chemistry 2010, 53, 8523 - 8533.
Nodwell, M. ; Zimmerman, C. ; Roberge, M. ; Andersen, R. J. Synthetic Analogues Of The Microtubule-Stabilizing Sponge Alkaloid Ceratamine A Are More Active Than The Natural Product. Journal of Medicinal Chemistry 2010, 53, 7843 - 7851.

2009

Carr, G. ; Tay, W. ; Bottriell, H. ; Andersen, S. K. ; Mauk, A. G. ; Andersen, R. J. Plectosphaeroic Acids A, B, And C, Indoleamine 2,3-Dioxygenase Inhibitors Produced In Culture By A Marine Isolate Of The Fungus Plectosphaerella Cucumerina. Organic Letters 2009, 11, 2996-2999.
Williams, D. E. ; Yu, K. ; Behrisch, H. W. ; Van Soest, R. ; Andersen, R. J. Rolloamides A And B, Cytotoxic Cyclic Heptapeptides Isolated From The Caribbean Marine Sponge Eurypon Laughlini. Journal of Natural Products 2009, 72, 1253-1257.
Pereira, A. ; Pfeifer, T. A. ; Grigliatti, T. A. ; Andersen, R. J. Functional Cell-Based Screening And Saturation Transfer Double-Difference Nmr Have Identified Haplosamate A As A Cannabinoid Receptor Agonist. Acs Chemical Biology 2009, 4, 139-144.
Nodwell, M. ; Pereira, A. ; Riffell, J. L. ; Zimmerman, C. ; Patrick, B. O. ; Roberge, M. ; Andersen, R. J. Synthetic Approaches To The Microtubule-Stabilizing Sponge Alkaloid Ceratamine A And Desbromo Analogues. Journal of Organic Chemistry 2009, 74, 995-1006.
Ho, C. H. ; Magtanong, L. ; Barker, S. L. ; Gresham, D. ; Nishimura, S. ; Natarajan, P. ; Koh, J. L. Y. ; Porter, J. ; Gray, C. A. ; Andersen, R. J. ; Giaever, G. ; Nislow, C. ; Andrews, B. ; Botstein, D. ; Graham, T. R. ; Yoshida, M. ; Boone, C. A Molecular Barcoded Yeast Orf Library Enables Mode-Of-Action Analysis Of Bioactive Compounds. Nature Biotechnology 2009, 27, 369-377.
Williams, D. E. ; Marques, S. O. ; Hajdu, E. ; Peixinho, S. ; Andersen, R. J. ; Berlinck, R. G. S. Pyrodysinoic Acid Derivatives From The Marine Sponge Dysidea Robusta. Journal of Natural Products 2009, 72, 1691-1694.
Forestier, R. ; Merchant, C. E. ; de Voogd, N. J. ; Matainaho, T. ; Kieffer, T. J. ; Andersen, R. J. Alotaketals A And B, Sesterterpenoids From The Marine Sponge Hamigera Species That Activate The Camp Cell Signaling Pathway. Organic Letters 2009, 11, 5166-5169.
Williams, D. E. ; Hollander, I. ; Feldberg, L. ; Frommer, E. ; Mallon, R. ; Tahir, A. ; Van Soest, R. ; Andersen, R. J. Scalarane-Based Sesterterpenoid Rce-Protease Inhibitors Isolated From The Indonesian Marine Sponge Carteriospongia Foliascens. Journal of Natural Products 2009, 72, 1106-1109.

2008

Volgraf, M. ; Lumb, J. P. ; Brastianos, H. C. ; Carr, G. ; Chung, M. K. W. ; Munzel, M. ; Mauk, A. G. ; Andersen, R. J. ; Trauner, D. Biomimetic Synthesis Of The Ido Inhibitors Exiguamine A And B. Nature Chemical Biology 2008, 4, 535-537.
Sadar, M. D. ; Williams, D. E. ; Mawji, N. R. ; Patrick, B. O. ; Wikanta, T. ; Chasanah, E. ; Irianto, H. E. ; Van Soest, R. ; Andersen, R. J. Sintokamides A To E, Chlorinated Peptides From The Sponge Dysidea Sp That Inhibit Transactivation Of The N-Terminus Of The Androgen Receptor In Prostate Cancer Cells. Organic Letters 2008, 10, 4947-4950.
Carr, G. ; Chung, M. K. W. ; Mauk, A. G. ; Andersen, R. J. Synthesis Of Indoleamine 2,3-Dioxygenase Inhibitory Analogues Of The Sponge Alkaloid Exiguamine A. Journal of Medicinal Chemistry 2008, 51, 2634-2637.
Sturgeon, C. M. ; Cinel, B. ; Diaz-Marrero, A. R. ; McHardy, L. M. ; Ngo, M. ; Andersen, R. J. ; Roberge, M. Abrogation Of Ionizing Radiation-Induced G(2) Checkpoint And Inhibition Of Nuclear Export By Cryptocarya Pyrones. Cancer Chemotherapy and Pharmacology 2008, 61, 407-413.
Ratnayake, R. ; Bandara, B. M. R. ; Wijesundara, D. S. A. ; Carr, G. ; Andersen, R. J. ; Karunaratne, V. Four New Butanolide Derivatives From Hortonia, A Genus Endemic To Sri Lanka. Journal of Chemical Research-S 2008, 134-136.
Nodwell, M. ; Riffell, J. L. ; Roberge, M. ; Andersen, R. J. Synthesis Of Antimitotic Analogs Of The Microtubule Stabilizing Sponge Alkaloid Ceratamine A. Organic Letters 2008, 10, 1051-1054.
Keyzers, R. A. ; Daoust, J. ; Davies-Coleman, M. T. ; Van Soest, R. ; Balgi, A. ; Donohue, E. ; Roberge, M. ; Andersen, R. J. Autophagy-Modulating Aminosteroids Isolated From The Sponge Cliona Celata. Organic Letters 2008, 10, 2959-2962.
Tarling, C. A. ; Woods, K. ; Zhang, R. ; Brastianos, H. C. ; Brayer, G. D. ; Andersen, R. J. ; Withers, S. G. The Search For Novel Human Pancreatic Alpha-Amylase Inhibitors: High-Throughput Screening Of Terrestrial And Marine Natural Product Extracts. Chembiochem 2008, 9, 433-438.
Williams, D. E. ; Davies, J. ; Patrick, B. O. ; Bottriell, H. ; Tarling, T. ; Roberge, M. ; Andersen, R. J. Cladoniamides A-G, Tryptophan-Derived Alkaloids Produced In Culture By Streptomyces Uncialis. Organic Letters 2008, 10, 3501-3504.
Diaz-Marrero, A. R. ; Matainaho, T. ; Van Soest, R. ; Roberge, M. ; Andersen, R. J. Scalarane-Based Metabolites Isolated From The Antimitotic Extract Of The Marine Sponge Hyrtios Erectus. Natural Product Research 2008, 22, 1304-1309.

2007

Carr, G. ; Raszek, M. ; Van Soest, R. ; Matainaho, T. ; Shopik, M. ; Holmes, C. F. B. ; Andersen, R. J. Protein Phosphatase Inhibitors Isolated From Spongia Irregularis Collected In Papua New Guinea. Journal of Natural Products 2007, 70, 1812-1815.
Williams, D. E. ; Sturgeon, C. M. ; Roberge, M. ; Andersen, R. J. Nigricanosides A And B, Antimitotic Glycolipids Isolated From The Green Alga Avrainvillea Nigricans Collected In Dominica. Journal of the American Chemical Society 2007, 129, 5822-+.
Warabi, K. ; Patrick, B. O. ; Austin, P. ; Roskelley, C. D. ; Roberge, M. ; Andersen, R. J. Strongylophorine-26, An Inhibitor Of Cancer Cell Invasion: Sar Revealed By Synthesis Of Analogues. Journal of Natural Products 2007, 70, 736-740.
Warabi, K. ; Williams, D. E. ; Patrick, B. O. ; Roberge, M. ; Andersen, R. J. Spirastrellolide B Reveals The Absolute Configuration Of The Spirastrellolide Macrolide Core. Journal of the American Chemical Society 2007, 129, 508-509.
Brastianos, H. C. ; Sturgeon, C. M. ; Roberge, M. ; Andersen, R. J. Inhibition Of The G(2) Dna Damage Checkpoint By Oliveroline Isolated From Duguetia Odorata. Journal of Natural Products 2007, 70, 287-288.
Williams, D. E. ; Keyzers, R. A. ; Warabi, K. ; Desjardine, K. ; Riffell, J. L. ; Roberge, M. ; Andersen, R. J. Spirastrellolides C To G: Macrolides Obtained From The Marine Sponge Spirastrella Coccinea. Journal of Organic Chemistry 2007, 72, 9842-9845.
Desjardine, K. ; Pereira, A. ; Wright, H. ; Matainaho, T. ; Kelly, M. ; Andersen, R. J. Tauramamide, A Lipopeptide Antibiotic Produced In Culture By Brevibacillus Laterosporus Isolated From A Marine Habitat: Structure Elucidation And Synthesis. Journal of Natural Products 2007, 70, 1850-1853.
de Lira, S. P. ; Seleghim, M. H. R. ; Williams, D. E. ; Marion, F. ; Hamill, P. ; Jean, F. ; Andersen, R. J. ; Hajdu, E. ; Berlinck, R. G. S. A Sars-Coronovirus 3Cl Protease Inhibitor Isolated From The Marine Sponge Axinella Cf. Corrugata: Structure Elucidation And Synthesis. Journal of the Brazilian Chemical Society 2007, 18, 440-443.
Ong, C. J. ; Ming-Lum, A. ; Nodwell, M. ; Ghanipour, A. ; Yang, L. ; Williams, D. E. ; Kim, J. ; Demirjian, L. ; Qasimi, P. ; Ruschmann, J. ; Cao, L. P. ; Ma, K. W. ; Chung, S. W. ; Duronio, V. ; Andersen, R. J. ; Krystal, G. ; Mui, A. L. F. Small-Molecule Agonists Of Shep1 Inhibit The Phosphoinositide 3-Kinase Pathway In Hematopoietic Cells. Blood 2007, 110, 1942-1949.

2006

Diaz-Marrero, A. R. ; Austin, P. ; Van Soest, R. ; Matainaho, T. ; Roskelley, C. D. ; Roberge, M. ; Andersen, R. J. Avinosol, A Meroterpenoid-Nucleoside Conjugate With Antiinvasion Activity Isolated From The Marine Sponge Dysidea Sp. Organic Letters 2006, 8, 3749-3752.
Barsby, T. ; Warabi, K. ; Sorensen, D. ; Zimmerman, W. T. ; Kelly, M. T. ; Andersen, R. J. The Bogorol Family Of Antibiotics: Template-Based Structure Elucidation And A New Approach To Positioning Enantiomeric Pairs Of Amino Acids. Journal of Organic Chemistry 2006, 71, 6031-6037.
Parsons, A. B. ; Lopez, A. ; Givoni, I. E. ; Williams, D. E. ; Gray, C. A. ; Porter, J. ; Chua, G. ; Sopko, R. ; Brost, R. L. ; Ho, C. H. ; Wang, J. Y. ; Ketela, T. ; Brenner, C. ; Brill, J. A. ; Fernandez, G. E. ; Lorenz, T. C. ; Payne, G. S. ; Ishihara, S. ; Ohya, Y. ; Andrews, B. ; Hughes, T. R. ; Frey, B. J. ; Graham, T. R. ; Andersen, R. J. ; Boone, C. Exploring The Mode-Of-Action Of Bioactive Compounds By Chemical-Genetic Profiling In Yeast. Cell 2006, 126, 611-625.
Murphy, S. ; Larrivee, B. ; Pollet, I. ; Craig, K. S. ; Williams, D. E. ; Huang, X. H. ; Abbott, M. ; Wong, F. ; Curtis, C. ; Conrads, T. P. ; Veenstra, T. ; Puri, M. ; Hsiang, Y. ; Roberge, M. ; Andersen, R. J. ; Karsan, A. Identification Of Sokotrasterol Sulfate As A Novel Proangiogenic Steroid. Circulation Research 2006, 99, 257-265.
To, K. C. W. ; Loh, K. T. ; Roskelley, C. D. ; Andersen, R. J. ; O’Connor, T. P. The Anti-Invasive Compound Motuporamine C Is A Robust Stimulator Of Neuronal Growth Cone Collapse. Neuroscience 2006, 139, 1263-1274.
Rundle, N. T. ; Nelson, J. ; Flory, M. R. ; Joseph, J. ; Th’ng, J. ; Aebersold, R. ; Dasso, M. ; Andersen, R. J. ; Roberge, M. An Ent-Kaurene That Inhibits Mitotic Chromosome Movement And Binds The Kinetochore Protein Ran-Binding Protein 2. Acs Chemical Biology 2006, 1, 443-450.
Pereira, A. ; Vottero, E. ; Roberge, M. ; Mauk, A. G. ; Andersen, R. J. Indoleamine 2,3-Dioxygenase Inhibitors From The Northeastern Pacific Marine Hydroid Garveia Annulata. Journal of Natural Products 2006, 69, 1496-1499.
Chen, S. ; Wang, J. Y. ; Muthusamy, B. P. ; Liu, K. ; Zare, S. ; Andersen, R. J. ; Graham, T. R. Roles For The Drs2P-Cdc50P Complex In Protein Transport And Phosphatidylserine Asymmetry Of The Yeast Plasma Membrane. Traffic 2006, 7, 1503-1517.
Gray, C. A. ; de Lira, S. P. ; Silva, M. ; Pimenta, E. F. ; Thiemann, O. H. ; Oliva, G. ; Hajdu, E. ; Andersen, R. J. ; Berlinck, R. G. S. Sulfated Meroterpenoids From The Brazilian Sponge Callyspongia Sp. Are Inhibitors Of The Antileishmaniasis Target Adenosine Phosphoribosyl Transferase. Journal of Organic Chemistry 2006, 71, 8685-8690.
Marion, F. ; Williams, D. E. ; Patrick, B. O. ; Hollander, I. ; Mallon, R. ; Kim, S. C. ; Roll, D. M. ; Feldberg, L. ; Van Soest, R. ; Andersen, R. J. Liphagal, A Selective Inhibitor Of Pi3 Kinase Alpha Isolated From The Sponge Aka Coralliphaga: Structure Elucidation And Biomimetic Synthesis. Organic Letters 2006, 8, 321-324.
Linington, R. G. ; Robertson, M. ; Gauthier, A. ; Finlay, B. B. ; MacMillan, J. B. ; Molinski, T. F. ; Van Soest, R. ; Andersen, R. J. Caminosides B-D, Antimicrobial Glycolipids Isolated From The Marine Sponge Caminus Sphaeroconia. Journal of Natural Products 2006, 69, 173-177.
Maynes, J. T. ; Luu, H. A. ; Cherney, M. M. ; Andersen, R. J. ; Williams, D. ; Holmes, C. F. B. ; James, M. N. G. Crystal Structures Of Protein Phosphatase-1 Bound To Motuporin And Dihydromicrocystin-La: Elucidation Of The Mechanism Of Enzyme Inhibition By Cyanobacterial Toxins. Journal of Molecular Biology 2006, 356, 111-120.
Brastianos, H. C. ; Vottero, E. ; Patrick, B. O. ; Van Soest, R. ; Matainaho, T. ; Mauk, A. G. ; Andersen, R. J. Exiguamine A, An Indoleamine-2,3-Dioxygenase (Ido) Inhibitor Isolated From The Marine Sponge Neopetrosia Exigua. Journal of the American Chemical Society 2006, 128, 16046-16047.

2005

Andersen, R. J. ; Taglialatela-Scafati, O. Avrainvilloside, A 6-Deoxy-6-Aminoglucoglycerolipid From The Green Alga Avrainvillea Nigricans. Journal of Natural Products 2005, 68, 1428-1430.
Williams, D. E. ; Austin, P. ; Diaz-Marrero, A. R. ; Van Soest, R. ; Matainaho, T. ; Roskelley, C. D. ; Roberge, M. ; Andersen, R. J. Neopetrosiamides, Peptides From The Marine Sponge Neopetrosia Sp That Inhibit Amoeboid Invasion By Human Tumor Cells. Organic Letters 2005, 7, 4173-4176.
Sturgeon, C. M. ; Craig, K. ; Brown, C. ; Rundle, N. T. ; Andersen, R. J. ; Roberge, M. Modulation Of The G(2) Cell Cycle Checkpoint By Sesquiterpene Lactones Psilostachyins A And C Isolated From The Common Ragweed Ambrosia Artemisiifolia. Planta Medica 2005, 71, 938-943.
Davies, J. ; Wang, H. ; Taylor, T. ; Warabi, K. ; Huang, X. H. ; Andersen, R. J. Uncialamycin, A New Enediyne Antibiotic. Organic Letters 2005, 7, 5233-5236.
McHardy, L. M. ; Warabi, K. ; Andersen, R. J. ; Roskelley, C. D. ; Roberge, M. Strongylophorine-26, A Rho-Dependent Inhibitor Of Tumor Cell Invasion That Reduces Actin Stress Fibers And Induces Nonpolarized Lamellipodial Extensions. Molecular Cancer Therapeutics 2005, 4, 772-778.
Williams, D. E. ; Patrick, B. O. ; Behrisch, H. W. ; Van Soest, R. ; Roberge, M. ; Andersen, R. J. Dominicin, A Cyclic Octapeptide, And Laughine, A Bromopyrrole Alkaloid, Isolated From The Caribbean Marine Sponge Eurypon Laughlini. Journal of Natural Products 2005, 68, 327-330.
Yang, L. ; Williams, D. E. ; Mui, A. ; Ong, C. ; Krystal, G. ; Van Soest, R. ; Andersen, R. J. Synthesis Of Pelorol And Analogues: Activators Of The Inositol 5-Phosphatase Ship. Organic Letters 2005, 7, 1073-1076.
Karsan, A. ; Pollet, I. ; Yu, L. R. ; Chan, K. C. ; Conrads, T. P. ; Lucas, D. A. ; Andersen, R. J. ; Veenstra, T. Quantitative Proteomic Analysis Of Sokotrasterol Sulfate-Stimulated Primary Human Endothelial Cells. Molecular & Cellular Proteomics 2005, 4, 191-204.
Karjala, G. ; Chan, Q. ; Manzo, E. ; Andersen, R. J. ; Roberge, N. Ceratamines, Structurally Simple Microtubule-Stabilizing Antimitotic Agents With Unusual Cellular Effects. Cancer Research 2005, 65, 3040-3043.

2004

Jiang, X. X. ; Zhao, B. G. ; Britton, R. ; Lim, L. Y. ; Leong, D. ; Sanghera, J. S. ; Zhou, B. B. S. ; Piers, E. ; Andersen, R. J. ; Roberge, M. Inhibition Of Chk1 By The G(2) Dna Damage Checkpoint Inhibitor Isogranulatimide. Molecular Cancer Therapeutics 2004, 3, 1221-1227.
Passreiter, C. M. ; Wilson, J. ; Andersen, R. J. ; Isman, M. B. Metabolism Of Thymol And Trans-Anethole In Larvae Of Spodoptera Litura And Trichoplusia Ni (Lepidoptera : Noctuidae). Journal of Agricultural and Food Chemistry 2004, 52, 2549-2551.
Baetz, K. ; McHardy, L. ; Gable, K. ; Tarling, T. ; Reberioux, D. ; Bryan, J. ; Andersen, R. J. ; Dunn, T. ; Hieter, P. ; Roberge, M. Yeast Genome-Wide Drug-Induced Haploinsufficiency Screen To Determine Drug Mode Of Action. Proceedings of the National Academy of Sciences of the United States of America 2004, 101, 4525-4530.
Williams, D. E. ; Lapawa, M. ; Feng, X. D. ; Tarling, T. ; Roberge, M. ; Andersen, R. J. Spirastrellolide A: Revised Structure, Progress Toward The Relative Configuration, And Inhibition Of Protein Phosphatase 2A. Organic Letters 2004, 6, 2607-2610.
Huang, X. H. ; Van Soest, R. ; Roberge, M. ; Andersen, R. J. Spiculoic Acids A And B, New Polyketides Isolated From The Caribbean Marine Sponge Plakortis Angulospiculatusi. Organic Letters 2004, 6, 75-78.
Warabi, K. ; Zimmerman, W. T. ; Shen, J. K. ; Gauthier, A. ; Robertson, M. ; Finlay, B. B. ; Van Soest, R. ; Andersen, R. J. Pachymoside A - A Novel Glycolipid Isolated From The Marine Sponge Pachymatisma Johnstonia. Canadian Journal of Chemistry-Revue Canadienne De Chimie 2004, 82, 102-112.
McHardy, L. M. ; Sinotte, R. ; Troussard, A. ; Sheldon, C. ; Church, J. ; Williams, D. E. ; Andersen, R. J. ; Dedhar, S. ; Roberge, M. ; Roskelley, C. D. The Tumor Invasion Inhibitor Dihydromotuporamine C Activates Rho, Remodels Stress Fibers And Focal Adhesions, And Stimulates Sodium-Proton Exchange. Cancer Research 2004, 64, 1468-1474.
Williams, D. E. ; Telliez, J. B. ; Liu, J. ; Tahir, A. ; Van Soest, R. ; Andersen, R. J. Meroterpenoid Mapkap (Mk2) Inhibitors Isolated From The Indonesian Marine Sponge Acanthodendrilla Sp. Journal of Natural Products 2004, 67, 2127-2129.
Andersen, R. J. ; Ireland, C. M. ; Molinski, T. F. ; Bewley, C. A. Research Achievement Award-D. John Faulkner. Journal of Natural Products 2004, 67, 1239-1251.
Warabi, K. ; McHardy, L. M. ; Matainaho, L. ; Van Soest, R. ; Roskelley, C. D. ; Roberge, M. ; Andersen, R. J. Strongylophorine-26, A New Meroditerpenoid Isolated From The Marine Sponge Petrosia (Strongylophora) Corticata That Exhibits Anti-Invasion Activity. Journal of Natural Products 2004, 67, 1387-1389.
MacMillan, J. B. ; Linington, R. G. ; Andersen, R. J. ; Molinski, T. F. Stereochemical Assignment In Acyclic Lipids Across Long Distance By Circular Dichroism: Absolute Stereochemistry Of The Aglycone Of Caminoside A. Angewandte Chemie-International Edition 2004, 43, 5946-5951.
Williams, D. E. ; Patrick, B. O. ; Tahir, A. ; Van Soest, R. ; Roberge, M. ; Andersen, R. J. Boneratamides A-C, New Sesquiterpenoids Isolated From The Marine Sponge Axinyssa Aplysinoides. Journal of Natural Products 2004, 67, 1752-1754.

2003

Linington, R. G. ; Williams, D. E. ; Tahir, A. ; Van Soest, R. ; Andersen, R. J. Latonduines A And B, New Alkaloids Isolated From The Marine Sponge Stylissa Carteri: Structure Elucidation, Synthesis, And Biogenetic Implications. Organic Letters 2003, 5, 2735-2738.
Nieman, J. A. ; Coleman, J. E. ; Wallace, D. J. ; Piers, E. ; Lim, L. Y. ; Roberge, M. ; Andersen, R. J. Synthesis And Antimitotic/cytotoxic Activity Of Hemiasterlin Analogues. Journal of Natural Products 2003, 66, 183-199.
Loganzo, F. ; Discafani, C. M. ; Annable, T. ; Beyer, C. ; Musto, S. ; Hari, M. ; Tan, X. Z. ; Hardy, C. ; Hernandez, R. ; Baxter, M. ; Singanallore, T. ; Khafizova, G. ; Poruchynsky, M. S. ; Fojo, T. ; Nieman, J. A. ; Ayral-Kaloustian, S. ; Zask, A. ; Andersen, R. J. ; Greenberger, L. M. Hti-286, A Synthetic Analogue Of The Tripeptide Hemiasterlin, Is A Potent Antimicrotubule Agent That Circumvents P-Glycoprotein-Mediated Resistance In Vitro And In Vivo. Cancer Research 2003, 63, 1838-1845.
van Altena, I. ; Van Soest, R. ; Roberge, M. ; Andersen, R. J. Trisphaerolide A, A Novel Polyketide From The Dominican Sponge Erylus Trisphaerus. Journal of Natural Products 2003, 66, 561-563.
Ireland, C. M. ; Aalbersberg, W. ; Andersen, R. J. ; Ayral-Kaloustian, S. ; Berlinck, R. G. S. ; Bernan, V. ; Carter, G. ; Churchill, A. C. L. ; Clardy, J. ; Concepcion, G. P. ; De Silva, E. D. ; Discafani, C. ; Fojo, T. ; Frost, P. ; Gibson, D. ; Greenberger, L. M. ; Greenstein, M. ; Harper, M. K. ; Mallon, R. ; Loganzo, F. ; Nunes, M. ; Poruchynsky, M. S. ; Zask, A. Anticancer Agents From Unique Natural Products Sources. Pharmaceutical Biology 2003, 41, 15-38.
Taglialatela-Scafati, O. ; Craig, K. S. ; Reberioux, D. ; Roberge, M. ; Andersen, R. J. Briarane, Erythrane, And Aquariane Diterpenoids From The Caribbean Gorgonian Erythropodium Caribaeorum. European Journal of Organic Chemistry 2003, 3515-3523.
Manzo, E. ; Van Soest, R. ; Matainaho, L. ; Roberge, M. ; Andersen, R. J. Ceratamines A And B, Antimitotic Heterocyclic Alkaloids Isolated From The Marine Sponge Pseudoceratina Sp Collected In Papua New Guinea. Organic Letters 2003, 5, 4591-4594.
Williams, D. E. ; Roberge, M. ; Van Soest, R. ; Andersen, R. J. Spirastrellolide A, An Antimitotic Macrolide Isolated From The Caribbean Marine Sponge Spirastrella Coccinea. Journal of the American Chemical Society 2003, 125, 5296-5297.
Yoo, H. D. ; Leung, D. ; Sanghara, J. ; Daley, D. ; Van Soest, R. ; Andersen, R. J. Isoarenarol, A New Protein Kinase Inhibitor From The Marine Sponge Dysidea Arenaria. Pharmaceutical Biology 2003, 41, 223-225.
Britton, R. ; Roberge, M. ; Brown, C. ; Van Soest, R. ; Andersen, R. J. New Okadaic Acid Analogues From The Marine Sponge Merriamum Oxeato And Their Effect On Mitosis. Journal of Natural Products 2003, 66, 838-843.

2002

Linington, R. G. ; Robertson, M. ; Gauthier, A. ; Finlay, B. B. ; van Soes, R. ; Andersen, R. J. Caminoside A, An Antimicrobial Glycolipid Isolated From The Marine Sponge Caminus Sphaeroconia. Organic Letters 2002, 4, 4089-4092.
Taglialatela-Scafati, O. ; Deo-Jangra, U. ; Campbell, M. ; Roberge, M. ; Andersen, R. J. Diterpenoids From Cultured Erythropodium Caribaeorum. Organic Letters 2002, 4, 4085-4088.
Craig, K. S. ; Williams, D. E. ; Hollander, I. ; Frommer, E. ; Mallon, R. ; Collins, K. ; Wojciechowicz, D. ; Tahir, A. ; Van Soest, R. ; Andersen, R. J. Novel Sesterterpenoid And Norsesterterpenoid Rce-Protease Inhibitors Isolated From The Marine Sponge Hippospongia Sp. Tetrahedron Letters 2002, 43, 4801-4804.
Williams, D. E. ; Craig, K. S. ; Patrick, B. ; McHardy, L. M. ; Van Soest, R. ; Roberge, M. ; Andersen, R. J. Motuporamines, Anti-Invasion And Anti-Angiogenic Alkaloids From The Marine Sponge Xestospongia Exigua (Kirkpatrick): Isolation, Structure Elucidation, Analogue Synthesis, And Conformational Analysis. Journal of Organic Chemistry 2002, 67, 245-258.
Yang, L. ; Andersen, R. J. Absolute Configuration Of The Antiinflamatory Sponge Natural Product Contignasterol. Journal of Natural Products 2002, 65, 1924-1926.
Wilson, J. M. B. ; Khabazian, I. ; Wong, M. C. ; Seyedalikhani, A. ; Bains, J. S. ; Pasqualotto, B. A. ; Williams, D. E. ; Andersen, R. J. ; Simpson, R. J. ; Smith, R. ; Craig, U. K. ; Kurland, L. T. ; Shaw, C. A. Behavioral And Neurological Correlates Of Als-Parkinsonism Dementia Complex In Adult Mice Fed Washed Cycad Flour. Neuromolecular Medicine 2002, 1, 207-221.
Barsby, T. ; Linington, R. G. ; Andersen, R. J. De Novo Terpenoid Biosynthesis By The Dendronotid Nudibranch Melibe Leonina. Chemoecology 2002, 12, 199-202.

2001

Curman, D. ; Cinel, B. ; Williams, D. E. ; Rundle, N. ; Block, W. D. ; Goodarzi, A. A. ; Hutchins, J. R. ; Clarke, P. R. ; Zhou, B. B. ; Lees-Miller, S. P. ; Andersen, R. J. ; Roberge, M. Inhibition Of The G(2) Dna Damage Checkpoint And Of Protein Kinases Chk1 And Chk2 By The Marine Sponge Alkaloid Debromohymenialdisine. Journal of Biological Chemistry 2001, 276, 17914-17919.
Williams, D. E. ; Allen, T. M. ; Van Soest, R. ; Behrisch, H. W. ; Andersen, R. J. Glanvillic Acids A And B And Methyl Capucinoate A, New Metabolites Isolated From The Caribbean Sponges Plakortis Halichondrioides And Plakinastrella Onkodes. Journal of Natural Products 2001, 64, 281-285.
Barsby, T. ; Kelly, M. T. ; Gagne, S. M. ; Andersen, R. J. Bogorol A Produced In Culture By A Marine Bacillus Sp Reveals A Novel Template For Cationic Peptide Antibiotics. Organic Letters 2001, 3, 437-440.
Britton, R. ; de Oliveira, J. ; Andersen, R. J. ; Berlinck, R. G. S. Granulatimide And 6-Bromogranulatimide, Minor Alkaloids Of The Brazilian Ascidian Didemnum Granulatum. Journal of Natural Products 2001, 64, 254-255.
Rundle, N. T. ; Xu, L. ; Andersen, R. J. ; Roberge, M. G(2) Dna Damage Checkpoint Inhibition And Antimitotic Activity Of 13-Hydroxy-15-Oxozoapatlin. Journal of Biological Chemistry 2001, 276, 48231-48236.
Britton, R. ; Roberge, M. ; Berisch, H. ; Andersen, R. J. Antimitotic Diterpenoids From Erythropodium Caribaeorum: Isolation Artifacts And Putative Biosynthetic Intermediates. Tetrahedron Letters 2001, 42, 2953-2956.
Fontana, A. ; Kelly, M. T. ; Prasad, J. D. ; Andersen, R. J. Evidence For The Biosynthesis Of Squalene Via The Methylerythritol Phosphate Pathway In A Streptomyces Sp Obtained From A Marine Sediment. Journal of Organic Chemistry 2001, 66, 6202-6206.
Roskelley, C. D. ; Williams, D. E. ; McHardy, L. M. ; Leong, K. G. ; Troussard, A. ; Karsan, A. ; Andersen, R. J. ; Dedhar, S. ; Roberge, M. Inhibition Of Tumor Cell Invasion And Angiogenesis By Motuporamines. Cancer Research 2001, 61, 6788-6794.
Britton, R. ; De Silva, E. D. ; Bigg, C. M. ; McHardy, L. M. ; Roberge, M. ; Andersen, R. J. Synthetic Transformations Of Eleutherobin Reveal New Features Of Its Microtubule-Stabilizing Pharmacophore. Journal of the American Chemical Society 2001, 123, 8632-8633.

2000

Roberge, M. ; Cinel, B. ; Anderson, H. J. ; Lim, L. ; Jiang, X. X. ; Xu, L. ; Bigg, C. M. ; Kelly, M. T. ; Andersen, R. J. Cell-Based Screen For Antimitotic Agents And Identification Of Analogues Of Rhizoxin, Eleutherobin, And Paclitaxel In Natural Extracts. Cancer Research 2000, 60, 5052-5058.
Xu, L. ; Patrick, B. O. ; Roberge, M. ; Allen, T. ; van Ofwegen, L. P. ; Andersen, R. J. New Diterpenoids From The Octocoral Pachyclavularia Violacea Collected In Papua New Guinea. Tetrahedron 2000, 56, 9031-9037.
Morris, R. J. ; Williams, D. E. ; Luu, H. A. ; Holmes, C. F. B. ; Andersen, R. J. ; Calvert, S. E. The Adsorption Of Microcystin-Lr By Natural Clay Particles. Toxicon 2000, 38, 303-308.
Cinel, B. ; Roberge, M. ; Behrisch, H. ; van Ofwegen, L. P. ; Castro, C. B. ; Andersen, R. J. Antimitotic Diterpenes From Erythropodium Caribaeorum Test Pharmacophore Models For Microtubule Stabilization. Organic Letters 2000, 2, 257-260.
Wang, G. Y. S. ; Graziani, E. ; Waters, B. ; Pan, W. B. ; Li, X. ; McDermott, J. ; Meurer, G. ; Saxena, G. ; Andersen, R. J. ; Davies, J. Novel Natural Products From Soil Dna Libraries In A Streptomycete Host. Organic Letters 2000, 2, 2401-2404.
Cinel, B. ; Patrick, B. O. ; Roberge, M. ; Andersen, R. J. Solid-State And Solution Conformations Of Eleutherobin Obtained From X-Ray Diffraction Analysis And Solution Noe Data. Tetrahedron Letters 2000, 41, 2811-2815.

1999

Ford, P. W. ; Gustafson, K. R. ; McKee, T. C. ; Shigematsu, N. ; Maurizi, L. K. ; Pannell, L. K. ; Williams, D. E. ; De Silva, E. D. ; Lassota, P. ; Allen, T. M. ; Van Soest, R. ; Andersen, R. J. ; Boyd, M. R. Papuamides A-D, Hiv-Inhibitory And Cytotoxic Depsipeptides From The Sponges Theonella Mirabilis And Theonella Swinhoei Collected In Papua New Guinea. Journal of the American Chemical Society 1999, 121, 5899-5909.
Gerard, J. M. ; Haden, P. ; Kelly, M. T. ; Andersen, R. J. Loloatins A-D, Cyclic Decapeptide Antibiotics Produced In Culture By A Tropical Marine Bacterium. Journal of Natural Products 1999, 62, 80-85.
Coleman, J. E. ; Van Soest, R. ; Andersen, R. J. New Geodiamolides From The Sponge Cymbastela Sp Collected In Papua New Guinea. Journal of Natural Products 1999, 62, 1137-1141.
Williams, D. E. ; Tahir, A. ; Andersen, R. J. A New Acyclic Diketotriterpenoid Isolated From The Indonesian Marine Sponge Hyrtios Erectus. Journal of Natural Products 1999, 62, 653-654.
Williams, D. E. ; Bernan, V. S. ; Ritacco, F. V. ; Maiese, W. M. ; Greenstein, M. ; Andersen, R. J. Holyrines A And B, Possible Intermediates In Staurosporine Biosynthesis Produced In Culture By A Marine Actinomycete Obtained From The North Atlantic Ocean. Tetrahedron Letters 1999, 40, 7171-7174.

1998

Williams, D. E. ; Lassota, P. ; Andersen, R. J. Motuporamines A-C, Cytotoxic Alkaloids Isolated From The Marine Sponge Xestospongia Exigua (Kirkpatrick). Journal of Organic Chemistry 1998, 63, 4838-4841.
Graziani, E. I. ; Andersen, R. J. Limaciamine, A New Diacylguanidine Isolated From The North Sea Nudibranch Limacia Clavigera. Journal of Natural Products 1998, 61, 285-286.
Kong, F. M. ; Graziani, E. I. ; Andersen, R. J. Madangamines B-E, Pentacyclic Alkaloids From The Marine Sponge Xestospongia Ingens. Journal of Natural Products 1998, 61, 267-271.
Williams, D. E. ; Bombuwala, K. ; Lobkovsky, E. ; De Silva, E. D. ; Karunaratne, V. ; Allen, T. M. ; Clardy, J. ; Andersen, R. J. Ambewelamides A And B, Antineoplastic Epidithiapiperazinediones Isolated From The Lichen Usnea Sp. Tetrahedron Letters 1998, 39, 9579-9582.
Berlinck, R. G. S. ; Britton, R. ; Piers, E. ; Lim, L. ; Roberge, M. ; da Rocha, R. M. ; Andersen, R. J. Granulatimide And Isogranulatimide, Aromatic Alkaloids With G2 Checkpoint Inhibition Activity Isolated From The Brazilian Ascidian Didemnum Granulatum: Structure Elucidation And Synthesis. Journal of Organic Chemistry 1998, 63, 9850-9856.
Roberge, M. ; Berlinck, R. G. S. ; Xu, L. ; Anderson, H. J. ; Lim, L. Y. ; Curman, D. ; Stringer, C. M. ; Friend, S. H. ; Davies, P. ; Vincent, I. ; Haggarty, S. J. ; Kelly, M. T. ; Britton, R. ; Piers, E. ; Andersen, R. J. High-Throughput Assay For G(2) Checkpoint Inhibitors And Identification Of The Structurally Novel Compound Isogranulatimide. Cancer Research 1998, 58, 5701-5706.
Ohba, M. ; Nishimura, Y. ; Imasho, M. ; Fujii, T. ; Kubanek, J. ; Andersen, R. J. Chiral Synthesis Of Tri-O-Methylimbricatine, An Etherified Derivative Of The Starfish Alkaloid Imbricatine. Tetrahedron Letters 1998, 39, 5999-6002.

1997

Williams, D. E. ; Craig, M. ; Dawe, S. C. ; Kent, M. L. ; Andersen, R. J. ; Holmes, C. F. B. C-14-Labeled Microcystin-Lr Administered To Atlantic Salmon Via Intraperitoneal Injection Provides In Vivo Evidence For Covalent Binding Of Microcystin-Lr In Salmon Livers. Toxicon 1997, 35, 985-989.
Dumdei, E. J. ; Kubanek, J. ; Coleman, J. E. ; Pika, J. ; Andersen, R. J. ; Steiner, J. R. ; Clardy, J. New Terpenoid Metabolites From The Skin Extracts, An Egg Mass, And Dietary Sponges Of The Northeastern Pacific Dorid Nudibranch Cadlina Luteomarginata. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1997, 75, 773-789.
Anderson, H. J. ; Coleman, J. E. ; Andersen, R. J. ; Roberge, M. Cytotoxic Peptides Hemiasterlin, Hemiasterlin A And Hemiasterlin B Induce Mitotic Arrest And Abnormal Spindle Formation. Cancer Chemotherapy and Pharmacology 1997, 39, 223-226.
Andersen, R. J. ; Coleman, J. E. ; Piers, E. ; Wallace, D. J. Total Synthesis Of (-)-Hemiasterlin, A Structurally Novel Tripeptide That Exhibits Potent Cytotoxic Activity. Tetrahedron Letters 1997, 38, 317-320.
Williams, D. E. ; Craig, M. ; Dawe, S. C. ; Kent, M. L. ; Holmes, C. F. B. ; Andersen, R. J. Evidence For A Covalently Bound Form Of Microcystin-Lr In Salmon Liver And Dungeness Crab Larvae. Chemical Research in Toxicology 1997, 10, 463-469.
Kubanek, J. ; Andersen, R. J. Evidence For The Incorporation Of Intact Butyrate Units In The Biosynthesis Of Triophamine. Tetrahedron Letters 1997, 38, 6327-6330.
Kubanek, J. ; Graziani, E. I. ; Andersen, R. J. Investigations Of Terpenoid Biosynthesis By The Dorid Nudibranch Cadlina Luteomarginata. Journal of Organic Chemistry 1997, 62, 7239-7246.
Williams, D. E. ; Dawe, S. C. ; Kent, M. L. ; Andersen, R. J. ; Craig, M. ; Holmes, C. F. B. Bioaccumulation And Clearance Of Microcystins From Salt Water, Mussels, Mytilus Edulis, And In Vivo Evidence For Covalently Bound Microcystins In Mussel Tissues. Toxicon 1997, 35, 1617-1625.
Singh, M. P. ; MroczenskiWildey, M. J. ; Steinberg, D. A. ; Andersen, R. J. ; Maiese, W. M. ; Greenstein, M. Biological Activity And Mechanistic Studies Of Andrimid. Journal of Antibiotics 1997, 50, 270-273.
Gerard, J. ; Lloyd, R. ; Barsby, T. ; Haden, P. ; Kelly, M. T. ; Andersen, R. J. Massetolides A-H, Antimycobacterial Cyclic Depsipeptides Produced By Two Pseudomonads Isolated From Marine Habitats. Journal of Natural Products 1997, 60, 223-229.

1996

Gerard, J. ; Haden, P. ; Kelly, M. T. ; Andersen, R. J. Loloatin B, A Cyclic Decapeptide Antibiotic Produced In Culture By A Tropical Marine Bacterium. Tetrahedron Letters 1996, 37, 7201-7204.
Graziani, E. I. ; Andersen, R. J. Investigations Of Sesquiterpenoid Biosynthesis By The Dorid Nudibranch Acanthodoris Nanaimoensis. Journal of the American Chemical Society 1996, 118, 4701-4702.
Graziani, E. I. ; Andersen, R. J. ; Krug, P. J. ; Faulkner, D. J. Stable Isotope Incorporation Evidence For The De Novo Biosynthesis Of Terpenoic Acid Glycerides By Dorid Nudibranchs. Tetrahedron 1996, 52, 6869-6878.
Williams, D. E. ; Craig, M. ; Holmes, C. F. B. ; Andersen, R. J. Ferintoic Acids A And B, New Cyclic Hexapeptides From The Freshwater Cyanobacterium Microcystis Aeruginosa. Journal of Natural Products 1996, 59, 570-575.
Coleman, J. E. ; Patrick, B. O. ; Andersen, R. J. ; Rettig, S. J. Hemiasterlin Methyl Ester. Acta Crystallographica Section C-Crystal Structure Communications 1996, 52, 1525-1527.
Sinclair, A. R. E. ; Williams, D. E. ; Andersen, R. J. ; Pain, J. Feeding Avoidance Of Balsam Poplar By Snowshoe Hares Is Related To Abundance Of Buds. Ecoscience 1996, 3, 223-225.
Craig, M. ; Luu, H. A. ; McCready, T. L. ; Williams, D. ; Andersen, R. J. ; Holmes, C. F. B. Molecular Mechanisms Underlying The Interaction Of Motuporin And Microycystins With Type-1 And Type-2A Protein Phosphatases. Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire 1996, 74, 569-578.

1995

Graziani, E. I. ; Allen, T. M. ; Andersen, R. J. Lovenone, A Cytotoxic Degraded Triterpenoid Isolated From Skin Extracts Of The North-Sea Dorid Nudibranch Adalaria-Loveni. Tetrahedron Letters 1995, 36, 1763-1766.
Bagy, J. R. ; Sonnichsen, F. D. ; Williams, D. ; Andersen, R. J. ; Sykes, B. D. ; Holmes, C. F. B. Comparison Of The Solution Structures Of Microcystin-Lr And Motuporin. Nature Structural Biology 1995, 2, 114-116.
Williams, D. E. ; Kent, M. L. ; Andersen, R. J. ; Klix, H. ; Holmes, C. F. B. Tissue Distribution And Clearance Of Tritium-Labeled Dihydromicrocystin-Lr Epimers Administered To Atlantic Salmon Via Intraperitoneal Injection. Toxicon 1995, 33, 125-131.
Kubanek, J. ; Williams, D. E. ; De Silva, E. D. ; Allen, T. ; Andersen, R. J. Cytotoxic Alkaloids From The Flatworm Prostheceraeus-Villatus And Its Tunicate Prey Clavelina-Lepadiformis. Tetrahedron Letters 1995, 36, 6189-6192.
Coleman, J. E. ; De Silva, E. D. ; Kong, F. M. ; Andersen, R. J. ; Allen, T. M. Cytotoxic Peptides From The Marine Sponge Cymbastela Sp. Tetrahedron 1995, 51, 10653-10662.

1994

Takei, M. ; Burgoyne, D. L. ; Andersen, R. J. Effect Of Contignasterol On Histamine-Release Induced By Antiimmunoglobulin-E From Rat Peritoneal Mast-Cells. Journal of Pharmaceutical Sciences 1994, 83, 1234-1235.
Kong, F. M. ; Andersen, R. J. ; Allen, T. M. Ingamine-A And Ingamine-B, New Cytotoxic Alkaloids From The Marine Sponge Xestospongia-Ingens. Tetrahedron 1994, 50, 6137-6144.
Kong, F. M. ; Andersen, R. J. ; Allen, T. M. Ingenamine, A Novel Pentacyclic Alkaloid From The Marine Sponge Xestospongia Ingens. Tetrahedron Letters 1994, 35, 1643-1646.
Kong, F. M. ; Andersen, R. J. ; Allen, T. M. Madangamine-A, A Novel Cytotoxic Alkaloid From The Marine Sponge Xestospongia-Ingens. Journal of the American Chemical Society 1994, 116, 6007-6008.

1993

Andersen, R. J. ; Burgoyne, D. L. ; Williams, D. E. ; Kong, F. M. ; De Silva, E. D. ; Miao, S. C. ; Allen, T. M. ; Holmes, C. F. B. ; Chen, D. ; Kent, M. New Natural-Products From Marine-Invertebrates. Gazzetta Chimica Italiana 1993, 123, 293-299.
Williams, D. E. ; Burgoyne, D. L. ; Rettig, S. J. ; Andersen, R. J. ; Fathiafshar, Z. R. ; Allen, T. M. The Isolation Of Majusculamide-C From The Sponge Ptilocaulis-Trachys Collected In Enewetak And Determination Of The Absolute-Configuration Of The 2-Methyl-3-Aminopentanoic Acid Residue. Journal of Natural Products 1993, 56, 545-551.
Andersen, R. J. ; Luu, H. A. ; Chen, D. Z. X. ; Holmes, C. F. B. ; Kent, M. L. ; Leblanc, M. ; Taylor, F. ; Williams, D. E. Chemical And Biological Evidence Links Microcystins To Salmon Netpen Liver-Disease. Toxicon 1993, 31, 1315-1323.
Rodgers, A. R. ; Williams, D. ; Sinclair, A. R. E. ; Sullivan, T. P. ; Andersen, R. J. Does Nursery Production Reduce Antiherbivore Defenses Of White Spruce - Evidence From Feeding Experiments With Snowshoe Hares. Canadian Journal of Forest Research-Revue Canadienne De Recherche Forestiere 1993, 23, 2358-2361.
Chen, D. Z. X. ; Boland, M. P. ; Smillie, M. A. ; Klix, H. ; Ptak, C. ; Andersen, R. J. ; Holmes, C. F. B. Identification Of Protein Phosphatase Inhibitors Of The Microcystin Class In The Marine-Environment. Toxicon 1993, 31, 1407-1414.
Dumdei, E. ; Andersen, R. J. Igzamide, A Metabolite Of The Marine Sponge Plocamissma-Igzo. Journal of Natural Products 1993, 56, 792-794.

1992

Needham, J. ; Andersen, R. J. ; Kelly, M. T. Biosynthesis Of Oncorhyncolide, A Metabolite Of The Seawater Bacterial Isolate Mk157. Journal of the Chemical Society-Chemical Communications 1992, 1367-1369.
Stingl, J. ; Andersen, R. J. ; Emerman, J. T. Invitro Screening Of Crude Extracts And Pure Metabolites Obtained From Marine-Invertebrates For The Treatment Of Breast-Cancer. Cancer Chemotherapy and Pharmacology 1992, 30, 401-406.
Pika, J. ; Tischler, M. ; Andersen, R. J. Glaciasterol-A And Glaciasterol-B, 9,11-Secosteroids From The Marine Sponge Aplysilla-Glacialis. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1992, 70, 1506-1510.
De Silva, E. D. ; Miao, S. C. ; Andersen, R. J. ; Schultz, L. W. ; Clardy, J. Trididemnic Acid-A And Acid-B, Aromatic Alkaloids From The Northeastern Pacific Ascidian Trididemnum Sp. Tetrahedron Letters 1992, 33, 2917-2920.
De Silva, E. D. ; Williams, D. E. ; Andersen, R. J. ; Klix, H. ; Holmes, C. F. B. ; Allen, T. M. Motuporin, A Potent Protein Phosphatase Inhibitor Isolated From The Papua-New-Guinea Sponge Theonella-Swinhoei Gray. Tetrahedron Letters 1992, 33, 1561-1564.
Kong, F. M. ; Burgoyne, D. L. ; Andersen, R. J. ; Allen, T. M. Pseudoaxinellin, A Cyclic Heptapeptide Isolated From The Papua-New-Guinea Sponge Pseudoaxinella-Massa. Tetrahedron Letters 1992, 33, 3269-3272.
Williams, D. E. ; Sinclair, A. R. E. ; Andersen, R. J. Triterpene Constituents Of The Dwarf Birch, Betula-Glandulosa. Phytochemistry 1992, 31, 2321-2324.
Burgoyne, D. L. ; Andersen, R. J. ; Allen, T. M. Contignasterol, A Highly Oxygenated Steroid With The Unnatural 14-Beta Configuration From The Marine Sponge Petrosia-Contignata Thiele, 1899. Journal of Organic Chemistry 1992, 57, 525-528.

1991

Needham, J. ; Andersen, R. J. ; Kelly, M. T. Oncorhyncolide, A Novel Metabolite Of A Bacterium Isolated From Seawater. Tetrahedron Letters 1991, 32, 315-318.
Burgoyne, D. L. ; Miao, S. ; Pathirana, C. ; Andersen, R. J. ; Ayer, W. A. ; Singer, P. P. ; Kokke, W. ; Ross, D. M. The Structure And Partial Synthesis Of Imbricatine, A Benzyltetrahydroisoquinoline Alkaloid From The Starfish Dermasterias-Imbricata. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1991, 69, 20-27.
Tischler, M. ; Andersen, R. J. ; Choudhary, M. I. ; Clardy, J. Terpenoids From The Sponge Aplysilla-Glacialis And Specimens Of The Nudibranch Cadlina-Luteomarginta Found On The Sponge. Journal of Organic Chemistry 1991, 56, 42-47.
Miao, S. C. ; Andersen, R. J. Callydiyne, A New Diacetylenic Hydrocarbon From The Sponge Callyspongia-Flammea. Journal of Natural Products 1991, 54, 1433-1434.
Morris, S. A. ; Northcote, P. T. ; Andersen, R. J. Triterpenoid Glycosides From The Northeastern Pacific Marine Sponge Xestospongia-Vanilla. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1991, 69, 1352-1364.
Miao, S. C. ; Andersen, R. J. Rubrolides-A-H, Metabolites Of The Colonial Tunicate Ritterella-Rubra. Journal of Organic Chemistry 1991, 56, 6275-6280.
Morris, S. A. ; De Silva, E. D. ; Andersen, R. J. Chromodorane Diterpenes From The Tropical Dorid Nudibranch Chromodoris-Cavae. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1991, 69, 768-771.
De Silva, E. D. ; Racok, J. S. ; Andersen, R. J. ; Allen, T. M. ; Brinen, L. S. ; Clardy, J. Neamphine, A Sulfur-Containing Aromatic Heterocycle Isolated From The Marine Sponge Neamphius-Huxleyi. Tetrahedron Letters 1991, 32, 2707-2710.
De Silva, E. D. ; Morris, S. A. ; Miao, S. C. ; Dumdei, E. ; Andersen, R. J. Terpenoid Metabolites From Skin Extracts Of 4 Sri-Lankan Nudibranchs In The Genus Chromodoris. Journal of Natural Products 1991, 54, 993-997.

1990

Miao, S. ; Andersen, R. J. ; Allen, T. M. Cytotoxic Metabolites From The Sponge Ianthella-Basta Collected In Papua-New-Guinea. Journal of Natural Products 1990, 53, 1441-1446.
Pathirana, C. ; Andersen, R. J. ; Wright, J. L. C. Abietinarin-A And Abietinarin-B, Cytotoxic Metabolites Of The Marine Hydroid Abietinaria-Sp. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1990, 68, 394-396.
Morris, S. A. ; Andersen, R. J. Brominated Bis(Indole) Alkaloids From The Marine Sponge Hexadella Sp. Tetrahedron 1990, 46, 715-720.
De Silva, E. D. ; Andersen, R. J. ; Allen, T. M. Geodiamolide-C To Geodiamolide-F, New Cytotoxic Cyclodepsipeptides From The Marine Sponge Pseudaxinyssa Sp. Tetrahedron Letters 1990, 31, 489-492.
Faulkner, D. J. ; Molinski, T. F. ; Andersen, R. J. ; Dumdei, E. J. ; De Silva, E. D. Geographical Variation In Defensive Chemicals From Pacific Coast Dorid-Nudibranchs And Some Related Marine Mollusks. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology 1990, 97, 233-240.

1989

Jogia, M. K. ; Andersen, R. J. ; Mantus, E. K. ; Clardy, J. Dysoxysulfone, A Sulfur Rich Metabolite From The Fijian Medicinal Plant Dysoxylum-Richii. Tetrahedron Letters 1989, 30, 4919-4920.
Pathirana, C. ; Andersen, R. J. ; Wright, J. C. L. Hydrallmanol-A, An Interesting Diphenyl-P-Menthane Derivative Of Mixed Biogenetic Origin From The Hydroid Hydrallmania-Falcata. Tetrahedron Letters 1989, 30, 1487-1490.
Dumdei, E. J. ; De Silva, E. D. ; Andersen, R. J. ; Choudhary, M. I. ; Clardy, J. Chromodorolide-A, A Rearranged Diterpene With A New Carbon Skeleton From The Indian-Ocean Nudibranch Chromodoris-Cavae. Journal of the American Chemical Society 1989, 111, 2712-2713.
Jogia, M. K. ; Andersen, R. J. ; Parkanyi, L. ; Clardy, J. ; Dublin, H. T. ; Sinclair, A. R. E. Crotofolane Diterpenoids From The African Shrub Croton-Dichogamus Pax. Journal of Organic Chemistry 1989, 54, 1654-1657.
Jogia, M. K. ; Andersen, R. J. Limonoids From The Fijian Medicinal Plant Dysoxylum-Richii. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1989, 67, 257-260.
Northcote, P. T. ; Andersen, R. J. Xestolide And Secoxestenone, Degraded Triterpenoids From The Sponge Xestospongia-Vanilla. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1989, 67, 1359-1362.
Northcote, P. T. ; Andersen, R. J. Xestovanin-A And Secoxestovanin-A, Triterpenoid Glycosides With New Carbon Skeletons From The Sponge Xestospongia-Vanilla. Journal of the American Chemical Society 1989, 111, 6276-6280.
Elliott, J. K. ; Ross, D. M. ; Pathirana, C. ; Miao, S. ; Andersen, R. J. ; Singer, P. ; Kokke, W. ; Ayer, W. A. Induction Of Swimming In Stomphia (Anthozoa, Actiniaria) By Imbricatine, A Metabolite Of The Asteroid Dermasterias-Imbricata. Biological Bulletin 1989, 176, 73-78.
Morris, S. A. ; Andersen, R. J. Nitrogenous Metabolites From The Deep-Water Sponge Hexadella Sp. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1989, 67, 677-681.
Jogia, M. K. ; Sinclair, A. R. E. ; Andersen, R. J. An Antifeedant In Balsam Poplar Inhibits Browsing By Snowshoe Hares. Oecologia 1989, 79, 189-192.

1988

Williams, D. E. ; Andersen, R. J. ; Kingston, J. F. ; Fallis, A. G. Minor Metabolites Of The Cold Water Soft Coral Gersemia-Rubiformis. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1988, 66, 2928-2934.
Tischler, M. ; Ayer, S. W. ; Andersen, R. J. ; Mitchell, J. F. ; Clardy, J. Anthosterone-A And Anthosterone-B, Ring-A Contracted Steroids From The Sponge Anthoracuata-Graceae. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1988, 66, 1173-1178.
Sinclair, A. R. E. ; Jogia, M. K. ; Andersen, R. J. Camphor From Juvenile White Spruce As An Antifeedant For Snowshoe Hares. Journal of Chemical Ecology 1988, 14, 1505-1514.
Northcote, P. T. ; Andersen, R. J. Xestenone, A New Bicyclic C19 Terpenoid From The Marine Sponge Xestospongia-Vanilla. Tetrahedron Letters 1988, 29, 4357-4360.

1987

Williams, D. E. ; Andersen, R. J. Terpenoid Metabolites From Skin Extracts Of The Dendronotid Nudibranch Tochuina-Tetraquetra. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1987, 65, 2244-2247.
Northcote, P. T. ; Andersen, R. J. Xestodiol, A New Apocarotenoid From The Sponge Xestospongia-Vanilla. Journal of Natural Products 1987, 50, 1174-1177.
Williams, D. ; Andersen, R. J. ; Vanduyne, G. D. ; Clardy, J. Cembrane And Pseudopterane Diterpenes From The Soft Coral Gersemia-Rubiformis. Journal of Organic Chemistry 1987, 52, 332-335.
Fahy, E. ; Andersen, R. J. Minor Metabolites Of The Marine Hydroid Garveia-Annulata. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1987, 65, 376-383.
Jogia, M. K. ; Andersen, R. J. Dysoxylin, A Limonoid From Dysoxylum-Richii. Phytochemistry 1987, 26, 3309-3311.
Boyer, G. L. ; Sullivan, J. J. ; Andersen, R. J. ; Harrison, P. J. ; Taylor, F. J. R. Effects Of Nutrient Limitation On Toxin Production And Composition In The Marine Dinoflagellate Protogonyaulax-Tamarensis. Marine Biology 1987, 96, 123-128.
Williams, D. E. ; Andersen, R. J. ; Parkanyi, L. ; Clardy, J. Gersolide, A Diterpenoid With A New Rearranged Carbon Skeleton From The Soft Coral Gersemia-Rubiformis. Tetrahedron Letters 1987, 28, 5079-5080.
Cembella, A. D. ; Sullivan, J. J. ; Boyer, G. L. ; Taylor, F. J. R. ; Andersen, R. J. Variation In Paralytic Shellfish Toxin Composition Within The Protogonyaulax-Tamarensis-Catenella Species Complex - Red Tide Dinoflagellates. Biochemical Systematics and Ecology 1987, 15, 171-186.

1986

Fahy, E. ; Andersen, R. J. ; Xu, C. F. ; Clardy, J. Annulin-A And Annulin-B, Metabolites Of The Marine Hydroid Garveia-Annulata. Journal of Organic Chemistry 1986, 51, 5145-5148.
Pathirana, C. ; Andersen, R. J. Imbricatine, An Unusual Benzyltetrahydroisoquinoline Alkaloid Isolated From The Starfish Dermasterias-Imbricata. Journal of the American Chemical Society 1986, 108, 8288-8289.
Williams, D. E. ; Ayer, S. W. ; Andersen, R. J. Diaulusterol-A And Diaulusterol-B From The Skin Extracts Of The Dorid Nudibranch Diaulula-Sandiegensis. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1986, 64, 1527-1529.
Tischler, M. ; Ayer, S. W. ; Andersen, R. J. Nitrophenols From Northeast Pacific Bryozoans. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology 1986, 84, 43-45.
Boyer, G. L. ; Sullivan, J. J. ; Andersen, R. J. ; Taylor, F. J. R. ; Harrison, P. J. ; Cembella, A. D. Use Of High-Performance Liquid-Chromatography To Investigate The Production Of Paralytic Shellfish Toxins By Protogonyaulax Spp In Culture. Marine Biology 1986, 93, 361-369.
Fahy, E. ; Andersen, R. J. ; Vanduyne, G. D. ; Clardy, J. Metabolites Of The Marine Hydroid Garveia-Annulata - Garveatin-B And Garveatin-C, 2-Hydroxygarvin-A, And Garvin-A Quinone. Journal of Organic Chemistry 1986, 51, 57-61.

1985

Gustafson, K. ; Andersen, R. J. Chemical Studies Of British-Columbia Nudibranchs. Tetrahedron 1985, 41, 1101-1108.
Fahy, E. ; Andersen, R. J. ; He, C. ; Clardy, J. Garveatin-A, An Antimicrobial 1(4H)-Anthracenone Derivative From The Hydroid Garveia-Annulata. Journal of Organic Chemistry 1985, 50, 1149-1150.
Gustafson, K. ; Andersen, R. J. ; He, C. H. ; Clardy, J. Marginatafuran, A Furanoditerpene With A New Carbon Skeleton From The Dorid Nudibranch Cadlina-Luteomarginata. Tetrahedron Letters 1985, 26, 2521-2524.

1984

Ayer, S. W. ; Andersen, R. J. ; He, C. H. ; Clardy, J. Acanthodoral And Isoacanthodoral, 2 Sesquiterpenoids With New Carbon Skeletons From The Dorid Nudibranch Acanthodoris-Nanaimoensis. Journal of Organic Chemistry 1984, 49, 2653-2654.
Pathirana, C. ; Andersen, R. J. Diterpenoids From The Brown Alga Dictyota-Binghamiae. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1984, 62, 1666-1671.
Trick, C. G. ; Andersen, R. J. ; Harrison, P. J. Environmental-Factors Influencing The Production Of An Antibacterial Metabolite From A Marine Dinoflagellate, Prorocentrum-Minimum. Canadian Journal of Fisheries and Aquatic Sciences 1984, 41, 423-432.
Ayer, S. W. ; Hellou, J. ; Tischler, M. ; Andersen, R. J. Nanaimoal, A Sesquiterpenoid Aldehyde From The Dorid Nudibranch Acanthodoris-Nanaimoensis. Tetrahedron Letters 1984, 25, 141-144.
Ayer, S. W. ; Andersen, R. J. ; He, C. H. ; Clardy, J. Phidolopin, A New Purine Derivative From The Bryozoan Phidolopora-Pacifica. Journal of Organic Chemistry 1984, 49, 3869-3870.
Gustafson, K. ; Andersen, R. J. ; Chen, M. H. M. ; Clardy, J. ; Hochlowski, J. E. Terpenoic Acid Glycerides From The Dorid Nudibranch Archidoris-Montereyensis. Tetrahedron Letters 1984, 25, 11-14.
Piers, E. ; Chong, J. M. ; Gustafson, K. ; Andersen, R. J. A Total Synthesis Of (+/-)-Triophamine. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1984, 62, 1-5.

1983

Trick, C. G. ; Andersen, R. J. ; Price, N. M. ; Gillam, A. ; Harrison, P. J. Examination Of Hydroxamate-Siderophore Production By Neritic Eukaryotic Marine-Phytoplankton. Marine Biology 1983, 75, 9-17.
Trick, C. G. ; Andersen, R. J. ; Gillam, A. ; Harrison, P. J. Prorocentrin - An Extracellular Siderophore Produced By The Marine Dinoflagellate Prorocentrum-Minimum. Science 1983, 219, 306-308.
Ayer, S. W. ; Andersen, R. J. Degraded Monoterpenes From The Opisthobranch Mollusk Melibe-Leonina. Experientia 1983, 39, 255-256.

1982

Ayer, S. W. ; Andersen, R. J. Steroidal Antifeedants From The Dorid Nudibranch Aldisa-Sanguinea-Cooperi. Tetrahedron Letters 1982, 23, 1039-1042.
Hellou, J. ; Andersen, R. J. ; Thompson, J. E. Terpenoids From The Dorid Nudibranch Cadlina-Luteomarginata. Tetrahedron 1982, 38, 1875-1879.
Gustafson, K. ; Andersen, R. J. Triophamine, A Unique Diacylguanidine From The Dorid Nudibranch Triopha-Catalinae (Cooper). Journal of Organic Chemistry 1982, 47, 2167-2169.

1981

Hellou, J. ; Andersen, R. J. ; Rafii, S. ; Arnold, E. ; Clardy, J. Luteone, A 23 Carbon Terpenoid From The Dorid Nudibranch Cadlina-Luteomarginata. Tetrahedron Letters 1981, 22, 4173-4176.

1980

Andersen, R. J. ; Leblanc, M. J. ; Sum, F. W. 1-(2,6,6-Trimethyl-4-Hydroxycyclohexenyl)-1,3-Butanedione, An Extracellular Metabolite From The Dinoflagellate Prorocentrum-Minimum. Journal of Organic Chemistry 1980, 45, 1169-1170.
Chan, A. T. ; Andersen, R. J. ; Leblanc, M. J. ; Harrison, P. J. Algal Plating As A Tool For Investigating Allelopathy Among Marine Microalgae. Marine Biology 1980, 59, 7-13.
Stonard, R. J. ; Andersen, R. J. Celenamide-A And Celenamide-B, Linear Peptide Alkaloids From The Sponge Cliona-Celata. Journal of Organic Chemistry 1980, 45, 3687-3691.
Andersen, R. J. ; Sum, F. W. Farnesic Acid Glycerides From The Nudibranch Archidoris-Odhneri. Tetrahedron Letters 1980, 21, 797-800.
Stonard, R. J. ; Andersen, R. J. Linear Peptide Alkaloids From The Sponge Cliona-Celata (Grant) Celenamides-C And Celenamide-D. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1980, 58, 2121-2126.
Stonard, R. J. ; Petrovich, J. C. ; Andersen, R. J. A New C-26 Sterol Peroxide From The Opisthobranch Mollusk Adalaria-Sp And The Sea Pen Virgularia-Sp. Steroids 1980, 36, 81-86.

1979

Andersen, R. J. ; Stonard, R. J. Clionamide, A Major Metabolite Of The Sponge Cliona-Celata Grant. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1979, 57, 2325-2328.

1978