@article {4156,
	title = {C-14-Labeled microcystin-LR administered to Atlantic salmon via intraperitoneal injection provides in vivo evidence for covalent binding of microcystin-LR in salmon livers},
	journal = {Toxicon},
	volume = {35},
	number = {6},
	year = {1997},
	note = {ISI Document Delivery No.: XG731Times Cited: 32Cited Reference Count: 18},
	month = {Jun},
	pages = {985-989},
	type = {Article},
	abstract = {The tissue distribution and clearance of radiolabeled microcystin-LR administered to Atlantic salmon via i.p. injection has been re-examined using uniformly C-14-labeled toxin, Significant differences were found to exist between these results and those obtained when fish received an i.p. injection of tritium-labeled dihydromicrocystin-LR. In addition, MeOH liver extracts were assayed by both phosphatase assay and C-14 counts and the results compared with the total levels of incorporation determined by digestion and subsequent C-14 counting of the same liver tissues. An attempt to investigate the metabolism and to document the putative products was also undertaken. It was found that microcystin-LR was extensively metabolized to compounds that are more polar than the parent compound. (C) 1997 Elsevier Science Ltd.},
	keywords = {biotransformation, CHROMATOGRAPHY, DIARRHETIC SHELLFISH TOXINS, DISEASE, IDENTIFICATION, INHIBITOR, POTENT, PROTEIN PHOSPHATASE, TISSUE DISTRIBUTION, TYPE-1},
	isbn = {0041-0101},
	url = {<Go to ISI>://A1997XG73100017},
	author = {Williams, D. E. and Craig, M. and Dawe, S. C. and Kent, M. L. and Andersen, R. J. and Holmes, C. F. B.}
}
