|Title||Sintokamides A to E, Chlorinated Peptides from the Sponge Dysidea sp that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Sadar, MD, Williams, DE, Mawji, NR, Patrick, BO, Wikanta, T, Chasanah, E, Irianto, HE, Van Soest, R, Andersen, RJ|
|Type of Article||Article|
|Keywords||AMINO-ACID, BARBAMIDE, biosynthesis, CYANOBACTERIUM, DOMAIN, HERBACEA, METABOLITES|
The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells.
|URL||<Go to ISI>://000260534500060|