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Total synthesis of (-)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity

TitleTotal synthesis of (-)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity
Publication TypeJournal Article
Year of Publication1997
AuthorsAndersen, RJ, Coleman, JE, Piers, E, Wallace, DJ
JournalTetrahedron Letters
Volume38
Pagination317-320
Date PublishedJan
Type of ArticleArticle
ISBN Number0040-4039
KeywordsALPHA-AMINO-ACIDS, ASYMMETRIC-SYNTHESIS, AZIDATION, PEPTIDES
Abstract

The total synthesis of (-)-hemiasterlin (2), a structurally novel, naturally occurring tripeptide that exhibits potent cytotoxic and antimitotic activity against human breast cancer MCF7 cells, is described. Copyright (C) 1996 Elsevier Science Ltd
URL<Go to ISI>://A1997WC80700005