Enhancing Metabolome Coverage in Data-Dependent LC–MS/MS Analysis through an Integrated Feature Extraction Strategy

In untargeted metabolomics, conventional data preprocessing software (e.g., XCMS, MZmine 2, MS-DIAL) are used extensively due to their high efficiency in metabolic feature extraction. However, these programs present limitations in recognizing low-abundance metabolic features, thus hindering complete metabolome coverage from the analysis. In this work, we explored the possibility of enhancing the metabolome coverage of data-dependent liquid chromatography–tandem mass spectrometry (LC–MS/MS) results by rescuing metabolic features that are missed by conventional software. To achieve this goal...


Dec 12 2019 - 3:00pm to 4:00pm
Dr. Jolene Reid
University of Utah, Department of Chemistry, Marie Curie Fellow
Mar 5 2020 - 6:30pm to 7:30pm
Dr. Katherine Elvira
Department of Chemistry, University of Victoria


The Department Mourns the Passing of Dr. William R. Cullen

Dr. William R. Cullen, FRSC, Professor Emeritus (Inorganic and Environmental Chemistry) passed away on December 1st, 2019. He was 86 years old.


Bill, a New Zealand cricketer with a knack for chemistry, from Dunedin on the South...

Congratulations to the Perrin Lab!

The Perrin lab's work on one-step, metal-free peptide stapling has been featured on the inside cover of Angewandte Chemie. Congratulations!

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