New agents for lowering blood sugar found in a common flowering garden plant

The complex plant flavonol glycoside montbretin A is a potent (K-i = 8 nM) and specific inhibitor of human pancreatic alpha-amylase with potential as a therapeutic for diabetes and obesity. Controlled degradation studies on montbretin A, coupled with inhibition analyses, identified an essential high-affinity core structure comprising the myricetin and caffeic acid moieties linked via a disaccharide. X-ray structural analyses of the montbretin A-human alpha-amylase complex confirmed the importance of this core structure and revealed a novel mode of glycosidase inhibition wherein internal pi...


Feb 9 2016 -
12:45pm to 2:00pm
Dr. Jayachandran N. Kizhakkedathu
Centre for Blood Research, Department of Pathology and Laboratory Medicine, Department of Chemistry, University of British Columbia
Feb 10 2016 -
12:00pm to 1:00pm
Gary Coyne
California State University, Los Angeles CA


Congratulations to the Ryan Group for their publication in Nature Chemical Biology!

A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond

Enzymes use organic cofactors to facilitate diverse chemical transformations. One of these cofactors, pyridoxal phosphate (PLP), is...

Congratulations to Dr. Curtis Berlinguette!

Congratulations to Dr. Curtis Berlinguette! Dr. Berlinguette has been awarded the STREM Chemical Award for Pure or Applied Inorganic Chemistry for his outstanding contribution to inorganic chemistry while demonstrating exceptional promise. The...

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