Research

Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...

Events

Apr 12 2021 - 10:00am to 11:00am
Dr. Ilsa R. Cooke
Marie Curie Postdoctoral Fellow, Institute of Physics Rennes
Apr 13 2021 - 3:00pm to 4:00pm
Dr. Nathan A. Seifert
Chemical Sciences & Engineering, Argonne National Laboratory
Apr 14 2021 - 10:00am to 11:00am
Dr. Katrin Dulitz
University of Freiburg, Institute of Physics

News

Takamasa Momose poses with the laser system at UBC. The main components of the system were designed and built by Momose and students in his lab. Credit: Takamasa Momose

World’s First Anti-Molecule Could Become a Reality Thanks to Laser-Cooled Antimatter

Researchers cool antimatter for the first time.

Researchers at the CERN-based ALPHA collaboration have cooled antimatter to near absolute zero for the first time,...

Russ Algar receives Charles A. McDowell Award for Excellence in Research

Prof. Russ Algar received the Charles A. McDowell Award for Excellence in Research. This award is given to a young faculty member who has demonstrated excellence in pure or applied scientific research. The Office of the VP, Research and...