Interrogating the thionium hydrogen bond as a noncovalent stereocontrolling interaction in chiral phosphate catalysis

CH⋯O bonds are a privileged noncovalent interaction determining the energies and geometries of a large number of structures. In catalytic settings, these are invoked as a decisive feature controlling many asymmetric transformations involving aldehydes. However, little is known about their stereochemical role when the interaction involves other substrate types. We report the results of computations that show for the first time thionium hydrogen bonds to be an important noncovalent interaction in asymmetric catalysis. As a validating case study, we explored an asymmetric Pummerer...


Dec 8 2022 - 10:00am to 1:00pm
Siwei Luo
UBC Chemistry (Thachuk Group)
Dec 9 2022 - 9:00am to 12:00pm
Luca Egoriti
UBC Chemistry/TRIUMF (MacFarlane & Gottberg Groups)


PhD Student Katrina Bergmann is Awarded The Vanier Canada Graduate Scholarship

Congratulations to PhD student Katrina Bergmann (Hudson Group) for receiving the Vanier Canada Graduate Scholarship!

The Vanier Canada Graduate Scholarship is the most prestigious and competitive of the doctoral scholarships offered by the...

Congratulations Sarah Burke

Congratulations to Dr. Sarah Burke for being awarded the 2022 Killam Mentoring Award!

Dr. Burke has been awarded for providing constant opportunities to hone essential skills in areas such as critical thinking, public speaking, and grant...