@article {9774,
	title = {Synthesis of Phosphatidylinositol 3-Kinase (PI3K) Inhibitory Analogues of the Sponge Meroterpenoid Liphagal.},
	journal = {Journal of Medicinal Chemistry},
	volume = {53},
	year = {2010},
	note = {CAPLUS AN 2010:1502709(Journal)},
	month = {2010///},
	pages = {8523 - 8533},
	publisher = {American Chemical Society},
	abstract = {The sponge meroterpenoid liphagal (+)-I and racemic and nonracemic analogs such as ({\textpm})-II were prepd. and their inhibition of phosphatidylinositol-3-kinases α and γ (PI3Kα and PI3Kγ, resp.) was detd. II inhibited PI3Kα and PI3Kγ with IC50 values of 66 nM and 1840 nM, resp., showing a 27-fold preference for PI3Kα; in addn., II exhibited enhanced chem. stability and modestly enhanced potency and selectivity compared with those of I. [on SciFinder(R)]},
	keywords = {liphagal stereoselective racemic nonracemic analog prepn phosphatidylinositol kinase inhibition, structure liphagal analog inhibition selectivity phosphatidylinositol kinase alpha gamma},
	isbn = {0022-2623},
	author = {Pereira,Alban R. and Strangman,Wendy K. and Marion,Frederic and Feldberg,Larry and Roll,Deborah and Mallon,Robert and Hollander,Irwin and Andersen, R. J.}
}
