|Title||Cladoniamides A-G, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Williams, DE, Davies, J, Patrick, BO, Bottriell, H, Tarling, T, Roberge, M, Andersen, RJ|
|Type of Article||Article|
|Keywords||biosynthesis, CHROMOPYRROLIC ACID, REBECCAMYCIN|
Cladoniamides A-G (3-9) have been isolated from cultures of Streptomyces uncialis, and their structures have been elucidated by a combination of spectroscopic analysis and an X-ray diffraction analysis of cladoniamide A (3). The cladoniamides have unprecedented rearranged and degraded alkaloid skeletons with putative biogenetic origins from indolocarbazole precursors. Cladoniamide G (9) is cytotoxic to MCF-7 cells in vitro at 10 mu g/mL.
|URL||<Go to ISI>://000258293100031|