| Title | Uncialamycin, a new enediyne antibiotic |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Davies, J, Wang, H, Taylor, T, Warabi, K, Huang, XH, Andersen, RJ |
| Journal | Organic Letters |
| Volume | 7 |
| Pagination | 5233-5236 |
| Date Published | Nov |
| Type of Article | Article |
| ISBN Number | 1523-7060 |
| Keywords | CALICHEAMICIN, DYNEMICIN-A, resistance |
| Abstract | Laboratory cultures of an undescribed streptomycete obtained from the surface of a British Columbia lichen produce uncialamycin (1), a new enediyne antibiotic. The structure of uncialamycin (1) has been elucidated by analysis of spectroscopic data. Uncialamycin (1) exhibits potent in vitro antibacterial activity against Gram-positive and Gram-negative human pathogens, including Burkholderia cepacia, a major cause of morbidity and mortality in patients with cystic fibrosis. |
| URL | <Go to ISI>://000233259000031 |
