@article {1692,
	title = {Protein phosphatase inhibitors isolated from Spongia irregularis collected in Papua New Guinea},
	journal = {Journal of Natural Products},
	volume = {70},
	number = {11},
	year = {2007},
	note = {Carr, Gavin Raszek, Mikolaj Van Soest, Rob Matainaho, Teatulohi Shopik, Micheal Holmes, Charles F. B. Andersen, Raymond J.},
	month = {Nov},
	pages = {1812-1815},
	abstract = {Irregularasulfate (1), a new nitrogen-containing sesterterpenoid, and the known sesterterpenoids hipposulfate C (2), halisulfate-7 (3), and igernellin (4), have been isolated from the marine sponge Spongia irregularis collected in Papua New Guinea. The structure of I was elucidated via analysis of its spectroscopic data. Sesterterpenoids 1, 2, and 3 are moderate inhibitors of the catalytic subunits of the mammalian Ser/Thr protein phosphatases calcineurin, PP-1, and PP-2A. The phosphate analogue of 3 and the thiophosphate analogue of 2 have been prepared from the corresponding natural products and evaluated for their ability to inhibit the phosphatase activity of calcineurin.},
	isbn = {0163-3864},
	url = {<Go to ISI>://000251179000023},
	author = {Carr, G. and Raszek, M. and Van Soest, R. and Matainaho, T. and Shopik, M. and Holmes, C. F. B. and Andersen, R. J.}
}
