|Title||Loloatins A-D, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium|
|Publication Type||Journal Article|
|Year of Publication||1999|
|Authors||Gerard, JM, Haden, P, Kelly, MT, Andersen, RJ|
|Journal||Journal of Natural Products|
|Type of Article||Article|
Loloatins A (1) to D (4), a family of new cyclic decapeptide antibiotics, have been isolated from laboratory cultures of a tropical marine bacterium recovered from the Great Barrier Reef in Papua New Guinea. The structures of loloatins A-D were elucidated via a combination of spectroscopic analyses and chemical degradation. Loloatins A-D exhibit in vitro antimicrobial activity against methicillin-resistant Staphyloccoccus aureus, vancomycin-resistant enterococci, and drug-resistant Streptococcus pneumoniae.
|URL||<Go to ISI>://000078186300014|