| Title | Novel natural products from soil DNA libraries in a streptomycete host |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Wang, GYS, Graziani, E, Waters, B, Pan, WB, Li, X, McDermott, J, Meurer, G, Saxena, G, Andersen, RJ, Davies, J |
| Journal | Organic Letters |
| Volume | 2 |
| Pagination | 2401-2404 |
| Date Published | Aug |
| Type of Article | Article |
| ISBN Number | 1523-7060 |
| Abstract | [GRAPHICS] As a route to accessing the potential chemical diversity of uncultivable microbes from the soil, combinatorial biosynthetic libraries were constructed by cloning large fragments of DNA isolated from soil into a Streptomyces lividans host. Four novel compounds, terragines A (1), B (2), C (3), and D (4), were isolated from recombinant 436-s4-5b1, and another novel compound, terragine E (5), was isolated from 446-s3-102g1. The structures were determined by a combination of spectroscopic techniques, primarily 2D NMR. |
| URL | <Go to ISI>://000088605200003 |
