@article {1876,
	title = {Small-molecule agonists of SHEP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells},
	journal = {Blood},
	volume = {110},
	number = {6},
	year = {2007},
	note = {Ong, Christopher J. Ming-Lum, Andrew Nodwell, Matt Ghanipour, Ali Yang, Lu Williams, David E. Kim, Joseph Demirjian, Loutfig Qasimi, Pooran Ruschmann, Jens Cao, Li-Ping Ma, Kewei Chung, Stephen W. Duronio, Vincent Andersen, Raymond J. Krystal, Gerald Mui, Alice L. -F.},
	month = {Sep},
	pages = {1942-1949},
	abstract = {Because phosphoinositide 3-kinase (PI3K) plays a central role in cellular activation, proliferation, and survival, pharmacologic inhibitors targeting components of the PI3K pathway are actively being developed as therapeutics for the treatment of inflammatory disorders and cancer. These targeted drugs inhibit the activity of either PI3K itself or downstream protein kinases. However, a previously unexplored, alternate strategy is to activate the negative regulatory phosphatases in this pathway. The SH2-containing inositol-5{\textquoteright}-phosphatase SHIP1 is a normal physiologic counter-regulator of PI3K in immune/hematopoietic cells that hydrolyzes the PI3K product phosphatidylinositiol-3,4,5-trisphosphate (PIPS). We now describe the identification and characterization of potent and specific small-molecule activators of SHIP1. These compounds represent the first small-molecule activators of a phosphatase, and are able to activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 cells. Mechanism of activation studies with these compounds suggest that they bind a previously undescribed, allosteric activation domain within SHIP1. Furthermore, in vivo administration of these compounds was protective in mouse models of endotoxemia and acute cutaneous anaphylaxis, suggesting that SHIP1 agonists could be used therapeutically to inhibit the PI3K pathway. activity in intact macrophage and mast},
	isbn = {0006-4971},
	url = {<Go to ISI>://000249671700038},
	author = {Ong, C. J. and Ming-Lum, A. and Nodwell, M. and Ghanipour, A. and Yang, L. and Williams, D. E. and Kim, J. and Demirjian, L. and Qasimi, P. and Ruschmann, J. and Cao, L. P. and Ma, K. W. and Chung, S. W. and Duronio, V. and Andersen, R. J. and Krystal, G. and Mui, A. L. F.}
}
