@article {4389,
	title = {High-throughput assay for G(2) checkpoint inhibitors and identification of the structurally novel compound isogranulatimide},
	journal = {Cancer Research},
	volume = {58},
	number = {24},
	year = {1998},
	note = {ISI Document Delivery No.: 148HTTimes Cited: 83Cited Reference Count: 39},
	month = {Dec},
	pages = {5701-5706},
	type = {Article},
	abstract = {Treatment of cancer cells lacking p53 function with G(2) checkpoint inhibitors sensitizes them to the toxic effects of DNA damage and has been proposed as a strategy for cancer therapy. However, few inhibitors are known, and they have been found serendipitously, We report the development of a G(2) checkpoint inhibition assay that is suitable for high-throughput screening and its application to a screen of 1300 natural extracts. We present the isolation of a new G(2) checkpoint inhibitor, the structurally novel compound isogranulatimide. In combination with gamma-irradiation, isogranulatimide selectively kills MCF-7 cells lacking p53 function.},
	keywords = {ANTITUMOR DRUG, BHK CELLS, CAFFEINE, CELL-CYCLE CHECKPOINTS, DNA-DAMAGE, HELA-CELLS, mitosis, P34(CDC2) KINASE, P53 FUNCTION, PREMATURE, PROTEIN KINASE-C},
	isbn = {0008-5472},
	url = {<Go to ISI>://000077499800017},
	author = {Roberge, M. and Berlinck, R. G. S. and Xu, L. and Anderson, H. J. and Lim, L. Y. and Curman, D. and Stringer, C. M. and Friend, S. H. and Davies, P. and Vincent, I. and Haggarty, S. J. and Kelly, M. T. and Britton, R. and Piers, E. and Andersen, R. J.}
}
