Chris Orvig

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Chris Orvig

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Research and Teaching Interests

TEACHING PHILOSOPHY

My basic teaching philosophy is to be enthusiastic about my subject, honest about potential confusions, and unambiguous in my explanations. I involve students in every lecture through a variety of mechanisms (call-and-response, intimate tutorials in which the students tell each other the answers using the chalkboard and I act as a facilitator, spot-the-trend checks, student papers/seminars, etc.). I try to make students feel that the lecture could not take place without them. I extensively use clear handouts so that the principles, not the details, are emphasized as being of importance. I de-emphasize memory work, and I stress the importance of integration of knowledge in the problem sets and exams (I tell the students this). Regurgitation is not part of my teaching philosophy.

RESEARCH PROGRAMME

Research projects in our labs study the roles of metal ions in the etiology, diagnosis, and therapy of disease. These projects encompass a variety of metal ions as well as numerous ligand systems and a wide panoply of techniques and collaborations. Synthesis of organic ligands and inorganic complexes as well as physical (potentiometric and spectrophotometric titrations, various spectroscopies, electrochemistry etc.) and biological studies (in cells, at UBC Bioservices and/or in collaboration) are undertaken in the research programme.

Contact

Real name: 
Email: 
Office Room Number(s): 
Chem D316
Office Phone Number: 
604-822-4449
Lab Room: 
D419, D421, D423
Lab Phone: 
604-822-8632
Fax Number: 
604-822-2847

Curriculum Vitae

Education:  Selwyn House School (1962-1971); B.Sc., McGill University (1971-1976); Ph.D., M.I.T. - NSERC Postgraduate Scholar (A. Davison, FRS, 1977-1981); NSERC Postdoctoral Fellow, University of California, Berkeley (K. N. Raymond, 1981-83); Postdoc, McMaster University (C. J. L. Lock, 1983-1984).  Director, Medicinal Inorganic Chemistry Group. 

Awards:  Fellow, Chemical Institute of Canada (1992).  UBC Killam Faculty Research Fellowship (1992‑1993).  Society of Pure and Applied Coordination Chemistry (SPACC) of Japan Award (1996).  UBC Faculty of Science Killam Teaching Prize (1998).  Alexander von Humboldt Foundation Research Award (1999-2000, 2013).  UBC Faculty of Science Achievement Award for Service (2005).  UBC Killam Faculty Research Prize (2006).  University of Sydney Foundation for Inorganic Chemistry Lectures 2006.  JSPS (Japan Society for the Promotion of Science) Invitation Fellow (2007).  Rio Tinto Alcan Award, Canadian Society for Chemistry (2009).  Bioinorganic Chemistry Award, Royal Society of Chemistry (2009).  Fellow of the Royal Society of Canada (2010).  Davison Lecturer, MIT (2011).  Canada Council Killam Research Fellowship (2011-13).  University of Canterbury (NZ) Visiting Erskine Fellow (2013).  UBC Jacob Biely Research Prize (2013).  G. Ronald Brown Lecturer, McGill University (2014). 

Honorary Positions:  International Symposium on Applied Bioinorganic Chemistry (ISABC) International Advisory Committee (2001-  ).  International Conference on Biological Inorganic Chemistry (ICBIC) International Organizing Committee (2007-  ).  Executive Secretary, International Conferences on Coordination Chemistry (2012-  ).  Humboldt Ambassador Scientist, Alexander von Humboldt-Stiftung, Germany (2015-2018).

Publications

2016

Ramogida, C. F. ; Murphy, L. ; Cawthray, J. F. ; Ross, J. D. ; Adam, M. J. ; Orvig, C. Novel “Bi-Modal” H2Dedpa Derivatives For Radio- And Fluorescence Imaging. J. Inorg. Biochem. 2016, 162, 253 - 262.
Comba, P. ; Grimm, L. ; Orvig, C. ; Rück, K. ; Wadepohl, H. Synthesis And Coordination Chemistry Of Hexadentate Picolinic Acid Based Bispidine Ligands. Inorg. Chem. 2016, 55, 12531-12543.
Weekes, D. M. ; Ramogida, C. F. ; Jaraquemada-Pelaez, Mde Guadalu; Patrick, B. O. ; Apte, C. ; Kostelnik, T. I. ; Cawthray, J. F. ; Murphy, L. ; Orvig, C. Dipicolinate Complexes Of Gallium(Iii) And Lanthanum(Iii). Inorg. Chem. 2016, 55, 12544-12558.
Ramogida, C. F. ; Boros, E. ; Patrick, B. O. ; Zeisler, S. K. ; Kumlin, J. ; Adam, M. J. ; Schaffer, P. ; Orvig, C. Evaluation Of H(2)Chxdedpa, H(2)Dedpa- And H(2)Chxdedpa-N,n `-Propyl-2-Ni Ligands For Cu-64(Ii) Radiopharmaceuticals. Dalton Trans. 2016, 45, 13082-13090.
Mjos, K. Dralle; Cawthray, J. F. ; Polishchuk, E. ; Abrams, M. J. ; Orvig, C. Gallium(Iii) And Iron(Iii) Complexes Of Quinolone Antimicrobials. Dalton Trans. 2016, 45, 13146-13160.
Price, E. W. ; Edwards, K. J. ; Carnazza, K. E. ; Carlin, S. D. ; Zeglis, B. M. ; Adam, M. J. ; Orvig, C. ; Lewis, J. S. A Comparative Evaluation Of The Chelators H(4)Octapa And Chx-A"-Dtpa With The Therapeutic Radiometal Y-90. Nucl. Med. Biol. 2016, 43, 566-576.
Telpoukhovskaia, M. A. ; Patrick, B. O. ; Rodríguez-Rodríguez, C. ; Orvig, C. In Silico To In Vitro Screening Of Hydroxypyridinones As Acetylcholinesterase Inhibitors. Bioorg. Med. Chem. Lett. 2016, 26, 1624-1628.
Abrams, M. J. ; Kronauge, J. ; Lister-James, J. ; Mahmood, A. ; Nicholson, T. ; Orvig, C. Alan Davison, Frs. Nucl. Med. Biol. 2016, 43, 189-190.
Ramogida, C. F. ; Schindler, D. ; Schneider, C. ; Tan, Y. [space]L. K. ; Huh, S. ; Ferreira, C. L. ; Adam, M. J. ; Orvig, C. Synthesis And Characterization Of Lipophilic Cationic Ga(Iii) Complexes Based On The H2Chxdedpa And H2Dedpa Ligands And Their 67/68Ga Radiolabeling Studies. RSC Adv. 2016, 6, 103763-103773.

2015

Rodriguez-Rodriguez, C. ; Telpoukhovskaia, M. A. ; Ali-Torres, J. ; Rodriguez-Santiago, L. ; Manso, Y. ; Bailey, G. A. ; Hidalgo, J. ; Sodupe, M. ; Orvig, C. Thioflavin-Based Molecular Probes For Application In Alzheimer's Disease: From In Silico To In Vitro Models. Metallomics 2015, 7, 83-92.
Mjos, K. Dralle; Cawthray, J. F. ; Jamieson, G. ; Fox, J. A. ; Orvig, C. Iron(Iii)-Binding Of The Anticancer Agents Doxorubicin And Vosaroxin. Dalton Trans. 2015, 44, 2348-2358.
Cawthray, J. F. ; Creagh, A. L. ; Haynes, C. A. ; Orvig, C. Ion Exchange In Hydroxyapatite With Lanthanides}. Inorg. Chem. 2015, 54, 1440–1445.
Ramogida, C. F. ; Cawthray, J. F. ; Boros, E. ; Ferreira, C. L. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. H2Chxdedpa And H4Chxoctapa-Chiral Acyclic Chelating Ligands For (67/68)Ga And (111)In Radiopharmaceuticals}. Inorg. Chem. 2015, 54, 2017–2031.
Ramogida, C. F. ; Pan, J. ; Ferreira, C. L. ; Patrick, B. O. ; Rebullar, K. ; Yapp, D. T. T. ; Lin, K. - S. ; Adam, M. J. ; Orvig, C. Nitroimidazole-Containing H(2)Dedpa And H(2)Chxdedpa Derivatives As Potential Pet Imaging Agents Of Hypoxia With Ga-68. Inorg. Chem. 2015, 54, 4953-4965.
Bertrand, B. ; Spreckelmeyer, S. ; Bodio, E. ; Cocco, F. ; Picquet, M. ; Richard, P. ; Le Gendre, P. ; Orvig, C. ; Cinellu, M. A. ; Casini, A. Exploring The Potential Of Gold(Iii) Cyclometallated Compounds As Cytotoxic Agents: Variations On The C^n Theme. Dalton Trans. 2015, 44, 11911-11918.
Telpoukhovskaia, M. A. ; Cawthray, J. F. ; Rodríguez-Rodríguez, C. ; Scott, L. E. ; Page, B. D. G. ; Patrick, B. O. ; Orvig, C. 3-Hydroxy-4-Pyridinone Derivatives Designed For Fluorescence Studies To Determine Interaction With Amyloid Protein As Well As Cell Permeability. Bioorg. Med. Chem. Lett. 2015, 25, 3654–3657.
Cawthray, J. F. ; Weekes, D. M. ; Sivak, O. ; Creagh, A. L. ; Ibrahim, F. ; Iafrate, M. ; Haynes, C. A. ; Wasan, K. M. ; Orvig, C. In Vivo Study And Thermodynamic Investigation Of Two Lanthanum Complexes, La (Dpp) 3 And La (Xt), For The Treatment Of Bone Resorption Disorders. Chem. Sci. 2015, 6, 6439–6447.

2014

Spreckelmeyer, S. ; Orvig, C. ; Casini, A. Cellular Transport Mechanisms Of Cytotoxic Metallodrugs: An Overview Beyond Cisplatin. Molecules 2014, 19, 15584-15610.
Telpoukhovskaia, M. ; Rodríguez-Rodríguez, C. ; Cawthray, J. F. ; Scott, L. Emily; Page, B. D. G. ; Ali-Torres, J. ; Sodupe, M. ; Bailey, G. A. ; Patrick, B. O. ; Orvig, C. 3-Hydroxy-4-Pyridinone Derivatives As Metal Ion And Amyloid Binding Agents. Metallomics 2014, 6, 249-262.
Price, E. W. ; Orvig, C. Matching Chelators To Radiometals For Radiopharmaceuticals. Chem. Soc. Rev. 2014, 43, 260-290.
Price, E. W. ; Zeglis, B. M. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. H(6)Phospa-Trastuzumab: Bifunctional Methylenephosphonate-Based Chelator With Zr-89, In-111 And Lu-177. Dalton Trans. 2014, 43, 119-131.
Telpoukhovskaia, M. A. ; Rodríguez-Rodríguez, C. ; Scott, L. E. ; Page, B. D. G. ; Patrick, B. O. ; Orvig, C. Synthesis, Characterization, And Cytotoxicity Studies Of Cu(Ii), Zn(Ii), And Fe (Iii) Complexes Of N-Derivatized 3-Hydroxy-4-Pyridiones. J. Inorg. Biochem. 2014, 132, 59-66.
Mjos, K. Dralle; Orvig, C. Metallodrugs In Medicinal Inorganic Chemistry. Chem. Rev. 2014, 114, 4540-4563.
Price, E. W. ; Cawthray, J. F. ; Adam, M. J. ; Orvig, C. Modular Syntheses Of H(4)Octapa And H(2)Dedpa, And Yttrium Coordination Chemistry Relevant To Y-86/y-90 Radiopharmaceuticals. Dalton Trans. 2014, 43, 7176-7190.
Price, E. W. ; Ferreira, C. L. ; Adam, M. J. ; Orvig, C. High-Denticity Ligands Based On Picolinic Acid For 111In Radiochemistry. Can. J. Chem. 2014, 92, 695-705.
Price, E. W. ; Zeglis, B. M. ; Cawthray, J. F. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. What A Difference A Carbon Makes: H4Octapa Vs. H4C3Octapa, Ligands For In-111 And Lu-177 Radiochemistry. Inorg. Chem. 2014, 53, 10412-10431.

2013

Telpoukhovskaia, M. A. ; Patrick, B. O. ; Rodríguez-Rodríguez, C. ; Orvig, C. Exploring The Multifunctionality Of Thioflavin- And Deferiprone-Based Molecules As Acetylcholinesterase Inhibitors For Potential Application In Alzheimer’S Disease. Mol. BioSyst. 2013, 9, 792-805.
Mawani, Y. ; Cawthray, J. F. ; Chang, S. ; Sachs-Barrable, K. ; Weekes, D. M. ; Wasan, K. M. ; Orvig, C. In Vitro Studies Of Lanthanide Complexes For The Treatment Of Osteoporosis. Dalton Trans. 2013, 42, 5999-6011.
Ramogida, C. F. ; Orvig, C. Tumour Targeting With Radiometals For Diagnosis And Therapy. Chem. Commun. 2013, 49, 4720-4739.
Telpoukhovskaia, M. A. ; Orvig, C. Werner Coordination Chemistry And Neurodegeneration. Chem. Soc. Rev. 2013, 42, 1836-1846.
Dikanov, S. A. ; Liboiron, B. D. ; Orvig, C. Vo2+-Hydroxyapatite Complexes As Models For Vanadyl Coordination To Phosphate In Bone. Mol. Phys. 2013, 111, 2967-2979.
Price, E. W. ; Zeglis, B. M. ; Cawthray, J. F. ; Ramogida, C. F. ; Ramos, N. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. H 4 Octapa-Trastuzumab: Versatile Acyclic Chelate System For 111 In And 177 Lu Imaging And Therapy. J. Am. Chem. Soc. 2013, 135, 12707 - 12721.
Salas, P. F. ; Herrmann, C. ; Orvig, C. Metalloantimalarials. Chem. Rev. 2013, 113, 3450 - 3492.
Salas, P. F. ; Herrmann, C. ; Cawthray, J. F. ; Nimphius, C. ; Kenkel, A. ; Chen, J. ; de Kock, C. ; Smith, P. J. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. Structural Characteristics Of Chloroquine-Bridged Ferrocenophane Analogues Of Ferroquine May Obviate Malaria Drug-Resistance Mechanisms. J. Med. Chem. 2013, 56, 1596 - 1613.

2012

Bailey, G. A. ; Price, E. W. ; Zeglis, B. M. ; Ferreira, C. L. ; Boros, E. ; Lacasse, M. J. ; Patrick, B. O. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. H 2 Azapa: A Versatile Acyclic Multifunctional Chelator For 67 Ga, 64 Cu, 111 In, And 177 Lu. Inorg. Chem. 2012, 51, 12575 - 12589.
Rodríguez-Rodríguez, C. ; Telpoukhovskaia, M. ; Orvig, C. The Art Of Building Multifunctional Metal-Binding Agents From Basic Molecular Scaffolds For The Potential Application In Neurodegenerative Diseases. Coordination Chemistry Reviews 2012, 256, 2308 - 2332.
Herrmann, C. ; Salas, P. F. ; Cawthray, J. F. ; de Kock, C. ; Patrick, B. O. ; Smith, P. J. ; Adam, M. J. ; Orvig, C. 1,1'-Disubstituted Ferrocenyl Carbohydrate Chloroquine Conjugates As Potential Antimalarials. Organometallics 2012, 31, 5736 - 5747.
Herrmann, C. ; Salas, P. F. ; Patrick, B. O. ; de Kock, C. ; Smith, P. J. ; Adam, M. J. ; Orvig, C. Modular Synthesis Of 1,2- And 1,1'-Disubstituted Ferrocenyl Carbohydrate Chloroquine And Mefloquine Conjugates As Potential Antimalarial Agents. Organometallics 2012, 31, 5748 - 5759.
Boros, E. ; Cawthray, J. F. ; Ferreira, C. L. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. Evaluation Of The H 2 Dedpa Scaffold And Its Crgdyk Conjugates For Labeling With 64 Cu. Inorg. Chem. 2012, 51, 6279 - 6284.
Price, E. W. ; Cawthray, J. F. ; Bailey, G. A. ; Ferreira, C. L. ; Boros, E. ; Adam, M. J. ; Orvig, C. H 4 Octapa: An Acyclic Chelator For 111 In Radiopharmaceuticals. J. Am. Chem. Soc. 2012, 134, 8670 - 8683.
Boros, E. ; Ferreira, C. L. ; Yapp, D. T. T. ; Gill, R. K. ; Price, E. W. ; Adam, M. J. ; Orvig, C. Rgd Conjugates Of The H2Dedpa Scaffold: Synthesis, Labeling And Imaging With 68Ga. Nucl. Med. Biol. 2012, 39, 785 - 794.
Herrmann, C. ; Salas, P. F. ; Patrick, B. O. ; de Kock, C. ; Smith, P. J. ; Adam, M. J. ; Orvig, C. 1,2-Disubstituted Ferrocenyl Carbohydrate Chloroquine Conjugates As Potential Antimalarial Agents. Dalton Trans. 2012, 41, 6431-6442.
Esparza-Ruiz, A. ; Herrmann, C. ; Chen, J. ; Patrick, B. O. ; Polishchuk, E. ; Orvig, C. Synthesis And In Vitro Anticancer Activity Of Ferrocenyl-Aminoquinoline-Carboxamide Conjugates. Inorg. Chim. Acta 2012, 393, 276 - 283.

2011

Scott, L. E. ; Telpoukhovskaia, M. ; Rodríguez-Rodríguez, C. ; Merkel, M. ; Bowen, M. L. ; Page, B. D. G. ; Green, D. E. ; Storr, T. ; Thomas, F. ; Allen, D. D. ; Lockman, P. R. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. N-Aryl-Substituted 3-(Β-D-Glucopyranosyloxy)-2-Methyl-4(1H)-Pyridinones As Agents For Alzheimer’S Therapy. Chemical Science 2011, 2, 642-648.
Boros, E. ; Lin, Y. - H. Scott; Ferreira, C. L. ; Patrick, B. O. ; Häfeli, U. O. ; Adam, M. J. ; Orvig, C. One To Chelate Them All: Investigation Of A Versatile, Bifunctional Chelator For 64Cu, 99Mtc, Re And Co. Dalton Transactions 2011, 40, 6253-6259.
Boros, E. ; Ferreira, C. L. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. New Ga Derivatives Of The H2Dedpa Scaffold With Improved Clearance And Persistent Heart Uptake. Nucl. Med. Biol. 2011, 38, 1165-1174.

2010

Boros, E. ; Ferreira, C. L. ; Cawthray, J. F. ; Price, E. W. ; Patrick, B. O. ; Wester, D. W. ; Adam, M. J. ; Orvig, C. Acyclic Chelate With Ideal Properties For 68Ga Pet Imaging Agent Elaboration. Journal of the American Chemical Society 2010, 132, 15726 - 15733.
Ferreira, C. L. ; Marques, F. L. N. ; Okamoto, M. R. Y. ; Otake, A. H. ; Sugai, Y. ; Mikata, Y. ; Storr, T. ; Bowen, M. ; Yano, S. ; Adam, M. J. ; Chammas, R. ; Orvig, C. Cationic Technetium And Rhenium Complexes With Pendant Carbohydrates. Applied Radiation and Isotopes 2010, 68, 1087 - 1093.
Green, D. E. ; Bowen, M. L. ; Scott, L. E. ; Storr, T. ; Merkel, M. ; Boehmerle, K. ; Thompson, K. H. ; Patrick, B. O. ; Schugar, H. J. ; Orvig, C. In Vitro Studies Of 3-Hydroxy-4-Pyridinones And Their Glycosylated Derivatives As Potential Agents For Alzheimer’S Disease. Dalton Transactions 2010, 39, 1604 - 1615.
Saha, B. ; Orvig, C. Biosorbents For Hexavalent Chromium Elimination From Industrial And Municipal Effluents. Coordination Chemistry Reviews 2010, 254, 2959 - 2972.

2009

Bordbar, A. K. ; Creagh, A. L. ; Mohammadi, F. ; Haynes, C. A. ; Orvig, C. Calorimetric Studies Of The Interaction Between The Insulin-Enhancing Drug Candidate Bis(Maltolato)Oxovanadium(Iv) (Bmov) And Human Serum Apo-Transferrin. Journal of Inorganic Biochemistry 2009, 103, 643-647.
Thompson, K. H. ; Lichter, J. ; Lebel, C. ; Scaife, M. C. ; McNeill, J. H. ; Orvig, C. Vanadium Treatment Of Type 2 Diabetes: A View To The Future. Journal of Inorganic Biochemistry 2009, 103, 554-558.
Liu, Y. C. ; Chen, Z. F. ; Liu, L. M. ; Peng, Y. ; Hong, X. ; Yang, B. ; Liu, H. G. ; Liang, H. ; Orvig, C. Divalent Later Transition Metal Complexes Of The Traditional Chinese Medicine (Tcm) Liriodenine: Coordination Chemistry, Cytotoxicity And Dna Binding Studies. Dalton Transactions 2009, 10813-10823.
Chen, Z. F. ; Tan, M. X. ; Liu, L. M. ; Liu, Y. C. ; Wang, H. S. ; Yang, B. ; Peng, Y. ; Liu, H. G. ; Liang, H. ; Orvig, C. Cytotoxicity Of The Traditional Chinese Medicine (Tcm) Plumbagin In Its Copper Chemistry. Dalton Transactions 2009, 10824-10833.
Bowen, M. L. ; Lim, N. C. ; Ewart, C. B. ; Misri, R. ; Ferreira, C. L. ; Hafeli, U. ; Adam, M. J. ; Orvig, C. Glucosamine Conjugates Bearing N,n,o-Donors: Potential Imaging Agents Utilizing The [M(Co)(3)](+) Core (M = Re, Tc). Dalton Transactions 2009, 9216-9227.
Storr, T. ; Scott, L. E. ; Bowen, M. L. ; Green, D. E. ; Thompson, K. H. ; Schugar, H. J. ; Orvig, C. Glycosylated Tetrahydrosalens As Multifunctional Molecules For Alzheimer’S Therapy. Dalton Transactions 2009, 3034-3043.
Bowen, M. L. ; Chen, Z. F. ; Roos, A. M. ; Misri, R. ; Hafeli, U. ; Adam, M. J. ; Orvig, C. Long-Chain Rhenium And Technetium Glucosamine Conjugates. Dalton Transactions 2009, 9228-9236.
Marques, F. L. ; Storr, T. ; Okamoto, M. R. ; Otake, A. H. ; Ferreira, C. L. ; Buchpiguel, C. A. ; Chammas, R. ; Adam, M. J. ; Orvig, C. Pedant 991 Tricarbonil Or Bisoxo Diamine Complexes Of Carbohydrates As Potential Tumor Spect Imaging Agent. Journal of Labelled Compounds & Radiopharmaceuticals 2009, 52, S277-S277.
Chen, Z. F. ; Liu, Y. C. ; Liu, L. M. ; Wang, H. S. ; Qin, S. H. ; Wang, B. L. ; Bian, H. D. ; Yang, B. ; Fun, H. K. ; Liu, H. G. ; Liang, H. ; Orvig, C. Potential New Inorganic Antitumour Agents From Combining The Anticancer Traditional Chinese Medicine (Tcm) Liriodenine With Metal Ions, And Dna Binding Studies. Dalton Transactions 2009, 262-272.
Boros, E. ; Hafeli, U. O. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. Design, Synthesis, And Imaging Of Small Amphiphilic Rhenium And (99M)Technetium Tricarbonyl Complexes. Bioconjugate Chemistry 2009, 20, 1002-1009.
Lever, A. B. P. ; Orvig, C. ; Reedijk, J. Stan Kirschner-An Appreciation. Coordination Chemistry Reviews 2009, 253, 1970-1972.

2008

Lim, N. C. ; Ewart, C. B. ; Bowen, M. L. ; Ferreira, C. L. ; Barta, C. A. ; Adam, M. J. ; Orvig, C. Pyridine-Tert-Nitrogen-Phenol Ligands: N,n,o-Type Tripodal Chelates For The [M(Co)(3)](+) Core (M = Re, Tc). Inorganic Chemistry 2008, 47, 1337-1345.
Barta, C. A. ; Bayly, S. R. ; Read, P. W. ; Patrick, B. O. ; Thompson, R. C. ; Orvig, C. Molecular Architectures For Trimetallic D/f/d Complexes: Magnetic Studies Of A Lncu(2) Core. Inorganic Chemistry 2008, 47, 2294-2302.
Barta, C. A. ; Bayly, S. R. ; Read, P. W. ; Patrick, B. O. ; Thompson, R. C. ; Orvig, C. Molecular Architectures For Trimetallic D/f/d Complexes: Structural And Magnetic Properties Of A Lnni(2) Core. Inorganic Chemistry 2008, 47, 2280-2293.
Zhang, Y. A. ; Monga, V. ; Orvig, C. ; Wang, Y. A. Theoretical Studies Of The Tautomers Of Pyridinethiones. Journal of Physical Chemistry A 2008, 112, 3231-3238.
Bowen, M. L. ; Orvig, C. 99M-Technetium Carbohydrate Conjugates As Potential Agents In Molecular Imaging. Chemical Communications 2008, 5077-5091.
Scott, L. E. ; Page, B. D. G. ; Patrick, B. O. ; Orvig, C. Altering Pyridinone N-Substituents To Optimise Activity As Potential Prodrugs For Alzheimer’S Disease. Dalton Transactions 2008, 6364-6367.

2007

Ferreira, C. L. ; Lapi, S. ; Steele, J. ; Green, D. E. ; Ruth, T. J. ; Adam, M. J. ; Orvig, C. (55)Cobalt Complexes With Pendant Carbohydrates As Potential Pet Imaging Agents. Applied Radiation and Isotopes 2007, 65, 1303-1308.
Schugar, H. ; Green, D. E. ; Bowen, M. L. ; Scott, L. E. ; Storr, T. ; Bohmerle, K. ; Thomas, F. ; Allen, D. D. ; Lockman, P. R. ; Merkel, M. ; Thompson, K. H. ; Orvig, C. Combating Alzheimer’S Disease With Multifunctional Molecules Designed For Metal Passivation. Angewandte Chemie-International Edition 2007, 46, 1716-1718.
Barta, C. A. ; Sachs-Barrable, K. ; Jia, J. ; Thompson, K. H. ; Wasan, K. M. ; Orvig, C. Lanthanide Containing Compounds For Therapeutic Care In Bone Resorption Disorders. Dalton Transactions 2007, 5019-5030.
Storr, T. ; Merkel, M. ; Song-Zhao, G. X. ; Scott, L. E. ; Green, D. E. ; Bowen, M. L. ; Thompson, K. H. ; Patrick, B. O. ; Schugar, H. J. ; Orvig, C. Synthesis, Characterization, And Metal Coordinating Ability Of Multifunctional Carbohydrate-Containing Compounds For Alzheimer’S Therapy. Journal of the American Chemical Society 2007, 129, 7453-7463.

2006

Ferreira, C. L. ; Bayly, S. R. ; Green, D. E. ; Storr, T. ; Barta, C. A. ; Steele, J. ; Adam, M. J. ; Orvig, C. Carbohydrate-Appended 3-Hydroxy-4-Pyridinone Complexes Of The [M(Co)(3)](+) Core (M) Re, Tc-99M, Re-186). Bioconjugate Chemistry 2006, 17, 1321-1329.
Ferreira, C. L. ; Ewart, C. B. ; Barta, C. A. ; Little, S. ; Yardley, V. ; Martins, C. ; Polishchuk, E. ; Smith, P. J. ; Moss, J. R. ; Merkel, M. ; Adam, M. J. ; Orvig, C. Synthesis, Structure, And Biological Activity Of Ferrocenyl Carbohydrate Conjugates. Inorganic Chemistry 2006, 45, 8414-8422.
Thompson, K. H. ; Orvig, C. Metal Complexes In Medicinal Chemistry: New Vistas And Challenges In Drug Design. Dalton Transactions 2006, 761-764.
Thompson, K. H. ; Orvig, C. Vanadium In Diabetes: 100 Years From Phase 0 To Phase I. Journal of Inorganic Biochemistry 2006, 100, 1925-1935.
Ferreira, C. L. ; Ewart, C. B. ; Bayly, S. R. ; Patrick, B. O. ; Steele, J. ; Adam, M. J. ; Orvig, C. Glucosamine Conjugates Of Tricarbonylcyclopentadienyl Rhenium(I) And Technetium(I) Cores. Inorganic Chemistry 2006, 45, 6979-6987.
Storr, T. ; Thompson, K. H. ; Orvig, C. Design Of Targeting Ligands In Medicinal Inorganic Chemistry. Chemical Society Reviews 2006, 35, 534-544.
Kovacs, M. S. ; Monga, V. ; Patrick, B. O. ; Orvig, C. Lanthanide(Iii) And Group 13 Metal Ion Complexes Of Tripodal Amino Phosphinate Ligands. Dalton Transactions 2006, 31-38.
Thompson, K. H. ; Barta, C. A. ; Orvig, C. Metal Complexes Of Maltol And Close Analogues In Medicinal Inorganic Chemistry. Chemical Society Reviews 2006, 35, 545-556.

2005

Saatchi, K. ; Thompson, K. H. ; Patrick, B. O. ; Pink, M. ; Yuen, V. G. ; McNeill, J. H. ; Orvig, C. Coordination Chemistry And Insulin-Enhancing Behavior Of Vanadium Complexes With Maltol C6H6O3 Structural Isomers. Inorganic Chemistry 2005, 44, 2689-2697.
Monga, V. ; Patrick, B. O. ; Orvig, C. Group 13 And Lanthanide Complexes With Mixed O,s Anionic Ligands Derived From Maltol. Inorganic Chemistry 2005, 44, 2666-2677.
Liboiron, B. D. ; Thompson, K. H. ; Hanson, G. R. ; Lam, E. ; Aebischer, N. ; Orvig, C. New Insights Into The Interactions Of Serum Proteins With Bis(Maltolato)Oxovanadium(Iv): Transport And Biotransformation Of Insulin-Enhancing Vanadium Pharmaceuticals. Journal of the American Chemical Society 2005, 127, 5104-5115.
Monga, V. ; Thompson, K. H. ; Yuen, V. G. ; Sharma, V. ; Patrick, B. O. ; McNeill, J. H. ; Orvig, C. Vanadium Complexes With Mixed O,s Anionic Ligands Derived From Maltol: Synthesis, Characterization, And Biological Studies. Inorganic Chemistry 2005, 44, 2678-2688.
Saatchi, K. ; Patrick, B. O. ; Orvig, C. Coordination Chemistry Of P,o-Bidentate Phosphinophenolates With Ga3+ And In3+. Dalton Transactions 2005, 2268-2274.
Storr, T. ; Fisher, C. L. ; Mikata, Y. ; Yano, S. ; Adam, M. J. ; Orvig, C. A Glucosamine Dipicolylamine Conjugate Of Tc-99M(I) And Re-186(I) For Use In Imaging And Therapy. Dalton Transactions 2005, 654-655.
Green, D. E. ; Ferreira, C. L. ; Stick, R. V. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. Carbohydrate-Bearing 3-Hydroxy-4-Pyridinonato Complexes Of Gallium(Iii) And Indium(Iii). Bioconjugate Chemistry 2005, 16, 1597-1609.
Mohammadi, K. ; Thompson, K. H. ; Patrick, B. O. ; Storr, T. ; Martins, C. ; Polishchuk, E. ; Yuen, V. G. ; McNeill, J. H. ; Orvig, C. Synthesis And Characterization Of Dual Function Vanadyl, Gallium And Indium Curcumin Complexes For Medicinal Applications. Journal of Inorganic Biochemistry 2005, 99, 2217-2225.
Nakai, M. ; Sekiguchi, F. ; Obata, M. ; Ohtsuki, C. ; Adachi, Y. ; Sakurai, H. ; Orvig, C. ; Rehder, D. ; Yano, S. Synthesis And Insulin-Mimetic Activities Of Metal Complexes With 3-Hydroxypyridine-2-Carboxylic Acid. Journal of Inorganic Biochemistry 2005, 99, 1275-1282.
Storr, T. ; Obata, M. ; Fisher, C. L. ; Bayly, S. R. ; Green, D. E. ; Brudzinska, I. ; Mikata, Y. ; Patrick, B. O. ; Adam, M. J. ; Yano, S. ; Orvig, C. Novel Carbohydrate-Appended Metal Complexes For Potential Use In Molecular Imaging. Chemistry-a European Journal 2005, 11, 195-203.
Storr, T. ; Sugai, Y. ; Barta, C. A. ; Mikata, Y. ; Adam, M. J. ; Yano, S. ; Orvig, C. Carbohydrate-Appended 2,2 ’-Dipicolylamine Metal Complexes As Potential Imaging Agents. Inorganic Chemistry 2005, 44, 2698-2705.

2004

Thompson, K. H. ; Chiles, J. ; Yuen, V. G. ; Tse, J. ; McNeill, J. H. ; Orvig, C. Comparison Of Anti-Hyperglycemic Effect Amongst Vanadium, Molybdenum And Other Metal Maltol Complexes. Journal of Inorganic Biochemistry 2004, 98, 683-690.
Bayly, S. R. ; Fisher, C. L. ; Storr, T. ; Adam, M. J. ; Orvig, C. Carbohydrate Conjugates For Molecular Imaging And Radiotherapy: Tc-99M(I) And Re-186(I) Tricarbonyl Complexes Of N-(2 ’-Hydroxybenzyl)-2-Amino-2-Deoxy-D-Glucose. Bioconjugate Chemistry 2004, 15, 923-926.
Nakai, M. ; Obata, M. ; Sekiguchi, F. ; Kato, M. ; Shiro, M. ; Ichimura, A. ; Kinoshita, I. ; Mikuriya, M. ; Inohara, T. ; Kawabe, K. ; Sakurai, H. ; Orvig, C. ; Yano, S. Synthesis And Insulinomimetic Activities Of Novel Mono- And Tetranuclear Oxovanadium(Iv) Complexes With 3-Hydroxypyridine-2-Carboxylic Acid. Journal of Inorganic Biochemistry 2004, 98, 105-112.
Thompson, K. H. ; Bohmerle, K. ; Polishchuk, E. ; Martins, C. ; Toleikis, P. ; Tse, J. ; Yuen, V. ; McNeill, J. H. ; Orvig, C. Complementary Inhibition Of Synoviocyte, Smooth Muscle Cell Or Mouse Lymphoma Cell Proliferation By A Vanadyl Curcumin Complex Compared To Curcumin Alone. Journal of Inorganic Biochemistry 2004, 98, 2063-2070.
Thompson, K. H. ; Orvig, C. Vanadium Compounds In The Treatment Of Diabetes. In Metal Ions in Biological Systems, Vol 41: Metal Ions and Their Complexes in Medication; Metal Ions in Biological Systems, Vol 41: Metal Ions and Their Complexes in Medication; Marcel Dekker: New York, 2004; Vol. 41, pp. 221-252.

2003

Yuen, V. G. ; Bhanot, S. ; Battell, M. L. ; Orvig, C. ; McNeill, J. H. Chronic Glucose-Lowering Effects Of Rosiglitazone And Bis(Ethylmaltolato)Oxovanadium(Iv) In Zdf Rats. Canadian Journal of Physiology and Pharmacology 2003, 81, 1049-1055.
Thompson, K. H. ; Orvig, C. Boon And Bane Of Metal Ions In Medicine. Science 2003, 300, 936-939.
Bayly, S. R. ; Xu, Z. Q. ; Patrick, B. O. ; Rettig, S. J. ; Pink, M. ; Thompson, R. C. ; Orvig, C. Dlf Complexes With Uniform Coordination Geometry: Structural And Magnetic Properties Of An Lnni2 Core Supported By A Heptadentate Amine Phenol Ligand. Inorganic Chemistry 2003, 42, 1576-1583.
Storr, T. ; Mitchell, D. ; Buglyo, P. ; Thompson, K. H. ; Yuen, V. G. ; McNeill, J. H. ; Orvig, C. Vanadyl-Thiazolidinedione Combination Agents For Diabetes Therapy. Bioconjugate Chemistry 2003, 14, 212-221.
Thompson, K. H. ; Liboiron, B. D. ; Bellman, Y. ; Setyawati, I. A. ; Patrick, B. O. ; Karunaratne, V. ; Rawji, G. ; Wheeler, J. ; Sutton, K. ; Bhanot, S. ; Cassidy, C. ; McNeill, J. H. ; Yuen, V. G. ; Orvig, C. Preparation And Characterization Of Vanadyl Complexes With Bidentate Maltol-Type Ligands; In Vivo Comparisons Of Anti-Diabetic Therapeutic Potential. Journal of Biological Inorganic Chemistry 2003, 8, 66-74.

2002

Yano, S. ; Nakai, M. ; Sekiguchi, F. ; Obata, M. ; Kato, M. ; Shiro, M. ; Kinoshita, I. ; Mikuriya, M. ; Sakurai, H. ; Orvig, C. Mononuclear To Tetranuclear Structural Transformation In Vanadyl Complexes Of 3-Hydroxypyridine-2-Carboxylic Acid (H(2)Hpic). Chemistry Letters 2002, 916-917.
Song, B. ; Saatchi, K. ; Rawji, G. H. ; Orvig, C. Synthesis And Solution Studies Of The Complexes Of Pyrone Analogue Ligands With Vanadium(Iv) And Vanadium(V). Inorganica Chimica Acta 2002, 339, 393-399.
Semiz, S. ; Orvig, C. ; McNeill, J. H. Effects Of Diabetes, Vanadium, And Insulin On Glycogen Synthase Activation In Wistar Rats. Molecular and Cellular Biochemistry 2002, 231, 23-35.
Song, B. ; Storr, T. ; Liu, S. ; Orvig, C. Synthesis And Solution Studies Of The Complexes Of Trivalent Lanthanides With The Tetraazamacrocycle Teta-(Po)(2). Inorganic Chemistry 2002, 41, 685-692.
Thompson, K. H. ; Tsukada, Y. ; Xu, Z. M. ; Battell, M. ; McNeill, J. H. ; Orvig, C. Influence Of Chelation And Oxidation State On Vanadium Bioavailability, And Their Effects On Tissue Concentrations Of Zinc, Copper, And Iron. Biological Trace Element Research 2002, 86, 31-44.

2001

Xu, L. ; Pierreroy, J. ; Patrick, B. O. ; Orvig, C. Chemistry Of Re With N,n ’-Bis(2-Pyridylmethyl)Ethylenediamine (H(2)Pmen): Hydrolysis, Dehydrogenation, And Ternary Complexes. Inorganic Chemistry 2001, 40, 2005-2010.
Kovacs, M. S. ; Hein, P. ; Sattarzadeh, S. ; Patrick, B. O. ; Emge, T. J. ; Orvig, C. Complexes Of Phosphine-Phenolate Ligands With The [Re=O](3+) And [Re(Hnnc5H4N)(Nnc5H4N)](2+) Cores. Journal of the Chemical Society-Dalton Transactions 2001, 3015-3024.
Thompson, K. H. ; Orvig, C. Coordination Chemistry Of Vanadium In Metallopharmaceutical Candidate Compounds. Coordination Chemistry Reviews 2001, 219, 1033-1053.
Song, B. ; Kurokawa, G. S. ; Liu, S. ; Orvig, C. Proton- And Lanthanide-Coordinating Properties Of The Tetraaza Macrocycle (Edda-Ka)(2) In Aqueous Solution. Canadian Journal of Chemistry-Revue Canadienne De Chimie 2001, 79, 1058-1067.
Song, B. ; Reuber, J. ; Ochs, C. ; Hahn, F. E. ; Lugger, T. ; Orvig, C. Effects Of Sequential Replacement Of -Nh2 By -Oh In The Tripodal Tetraamine Tren On Its Acidity And Metal Ion Coordinating Properties. Inorganic Chemistry 2001, 40, 1527-1535.
Mikata, Y. ; Shinohara, Y. ; Yoneda, K. ; Nakamura, Y. ; Esaki, K. ; Tanahashi, M. ; Brudzinska, I. ; Hirohara, S. ; Yokoyama, M. ; Mogami, K. ; Tanase, T. ; Kitayama, T. ; Takashiba, K. ; Nabeshima, K. ; Takagi, R. ; Takatani, M. ; Okamoto, T. ; Kinoshita, I. ; Doe, M. ; Hamazawa, A. ; Morita, M. ; Nishida, F. ; Sakakibara, T. ; Orvig, C. ; Yano, S. Sugar-Pendant Diamines. Journal of Organic Chemistry 2001, 66, 3783-3789.
Mikata, Y. ; Shinohara, Y. ; Yoneda, K. ; Nakamura, Y. ; Brudzinska, I. ; Tanase, T. ; Kitayama, T. ; Takagi, R. ; Okamoto, T. ; Kinoshita, I. ; Doe, M. ; Orvig, C. ; Yano, S. Unprecedented Sugar-Dependent In Vivo Antitumor Activity Of Carbohydrate-Pendant Cis-Diamminedichloroplatinum(Ii) Complexes. Bioorganic & Medicinal Chemistry Letters 2001, 11, 3045-3047.
Melchior, M. ; Rettig, S. J. ; Liboiron, B. D. ; Thompson, K. H. ; Yuen, V. G. ; McNeill, J. H. ; Orvig, C. Insulin-Enhancing Vanadium(Iii) Complexes. Inorganic Chemistry 2001, 40, 4686-4690.
Yano, S. ; Shinohara, Y. ; Brudzinska, I. ; Mikata, Y. ; Orvig, C. Unprecedented Sugar-Dependent In Vivo Antitumor Activity Of Carbohydrate-Pendant Cis-Diamminedichloroplatinum(Ii) Complexes. Journal of Inorganic Biochemistry 2001, 86, 486-486.
Xu, L. ; Lowe, M. P. ; Rettig, S. J. ; Orvig, C. [Reo(N2O2)X] Complexes: "4+1"?. Inorganic Chemistry 2001, 40, 4623-4626.

2000

Xu, Z. Q. ; Read, P. W. ; Hibbs, D. E. ; Hursthouse, M. B. ; Malik, K. M. A. ; Patrick, B. O. ; Rettig, S. J. ; Seid, M. ; Summers, D. A. ; Pink, M. ; Thompson, R. C. ; Orvig, C. Coaggregation Of Paramagnetic D- And F-Block Metal Ions With A Podand-Framework Amine Phenol Ligand. Inorganic Chemistry 2000, 39, 508-516.
Setyawati, I. A. ; Liu, S. ; Rettig, S. J. ; Orvig, C. Homotrinuclear Lanthanide(Iii) Arrays: Assembly Of And Conversion From Mononuclear And Dinuclear Units. Inorganic Chemistry 2000, 39, 496-507.
Xu, L. ; Setyawati, I. A. ; Pierreroy, J. ; Pink, M. ; Young, V. G. ; Patrick, B. O. ; Rettig, S. J. ; Orvig, C. Seven-Coordinate [(Reon4X2)-O-V](+) Complexes (X = O And Cl). Inorganic Chemistry 2000, 39, 5958-5963.
Song, B. ; Mehrkhodavandi, P. ; Buglyo, P. ; Mikata, Y. ; Shinohara, Y. ; Yoneda, K. ; Yano, S. ; Orvig, C. Acid-Base And Metal Ion-Binding Properties Of Diaminopropyl D-Glucopyranoside And Diaminopropyl D-Mannopyranoside Compounds In Aqueous Solution. Journal of the Chemical Society-Dalton Transactions 2000, 8, 1325-1333.
Hein, P. ; Lugger, T. ; Hahn, F. E. ; Rettig, S. J. ; Orvig, C. Crystal Structure Of (2-Hydroxy-5-Methylphenyl)Diphenylphosphineoxide, C6H5)(2)P(O)(Ch3C6H3Oh). Zeitschrift Fur Kristallographie-New Crystal Structures 2000, 215, 237-238.
Thompson, K. H. ; McNeill, J. H. ; Orvig, C. Design Of New Oxovanadium (Iv) Complexes For Treatment Of Diabetes. Biovailability, Speciation, And Tissue Targeting Considerations. In Trace Elements in Man and Animals 10; Roussel, A. M. ; Anderson, R. A. ; Favrier, A. E. ; Trace Elements in Man and Animals 10; Kluwer Academic/Plenum Publ: New York, 2000; pp. 539-539.
Thompson, K. H. ; Orvig, C. Design Of Vanadium Compounds As Insulin Enhancing Agents. Journal of the Chemical Society-Dalton Transactions 2000, 2885-2892.

1999

Song, B. ; Mikata, Y. ; Shinohara, Y. ; Yoneda, K. ; Yano, S. ; Orvig, C. Acid-Base And Metal Ion-Binding Properties Of (2S)-2,3-Diaminopropyl Beta-D-Glucopyranoside (1-Beta-D-Glc-Pn) In Aqueous Solution. Journal of Inorganic Biochemistry 1999, 74, 300-300.
Thompson, K. H. ; McNeill, J. H. ; Orvig, C. Vanadium Compounds As Insulin Mimics. Chemical Reviews 1999, 99, 2561-2571.
Woo, L. C. Y. ; Yuen, V. G. ; Thompson, K. H. ; McNeill, J. H. ; Orvig, C. Vanadyl-Biguanide Complexes As Potential Synergistic Insulin Mimics. Journal of Inorganic Biochemistry 1999, 76, 251-257.
Ward, T. R. ; Lutz, A. ; Parel, S. P. ; Ensling, J. ; Gutlich, P. ; Buglyo, P. ; Orvig, C. An Iron-Based Molecular Redox Switch As A Model For Iron Release From Enterobactin Via The Salicylate Binding Mode. Inorganic Chemistry 1999, 38, 5007-5017.
Melchior, M. ; Thompson, K. H. ; Jong, J. M. ; Rettig, S. J. ; Shuter, E. ; Yuen, V. G. ; Zhou, Y. ; McNeill, J. H. ; Orvig, C. Vanadium Complexes As Insulin Mimetic Agents: Coordination Chemistry And In Vivo Studies Of Oxovanadium(Iv) And Dioxovanadate(V) Complexes Formed From Naturally Occurring Chelating Oxazolinate, Thiazolinate, Or Picolinate Units. Inorganic Chemistry 1999, 38, 2288-2293.
Yano, S. ; Shinohara, Y. ; Mogami, K. ; Yokoyama, M. ; Tanase, T. ; Sakakibara, T. ; Nishida, F. ; Mochida, K. ; Kinoshita, I. ; Doe, M. ; Ichihara, K. ; Naruta, Y. ; Mehrkhodavandi, P. ; Buglyo, P. ; Song, B. ; Orvig, C. ; Mikata, Y. General Synthesis Of Useful Chelating Reagents Having A Sugar Unit, 1,3-Diamino-2-Propyl Beta-D-Glucopyranoside And 1,3-Diamino-2-Propyl Alpha-D-Mannopyranoside. Chemistry Letters 1999, 255-256.
Setyawati, I. A. ; Rettig, S. J. ; Orvig, C. Cationic Iron(Iii) Complex With A Hexadentate N-2,n ’(2),o-2-Aminopyridylphenolate Ligand. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1999, 77, 2033-2038.
Dikanov, S. A. ; Liboiron, B. D. ; Thompson, K. H. ; Vera, E. ; Yuen, V. G. ; McNeill, J. H. ; Orvig, C. In Vivo Electron Spin-Echo Envelope Modulation (Eseem) Spectroscopy: First Observation Of Vanadyl Coordination To Phosphate In Bone. Journal of the American Chemical Society 1999, 121, 11004-11005.

1998

Stephens, A. K. W. ; Orvig, C. Complexation Of Ni2+ And Cu2+ By Tripodal Amine Phenol Ligands In Aqueous Solution. Journal of the Chemical Society-Dalton Transactions 1998, 3049-3056.
Bondy, S. C. ; Tseng, H. ; Orvig, C. Active Oxygen Species Formation In Synaptosomes Exposed To An Aluminum Chelator. Neurotoxicology and Teratology 1998, 20, 317-320.
Stephens, A. K. W. ; Orvig, C. Complexation Of Gallium(Iii) By 2-Hydroxynicotinic Acid And 3-Hydroxypicolinic Acid In Aqueous Solution. Inorganica Chimica Acta 1998, 273, 47-53.
Thompson, K. H. ; McNeill, J. H. ; Dai, S. ; Vera, E. ; Orvig, C. Compartmental Analysis Of Vanadium Metabolism In Male, Wistar Rats Given Graded Levels Of Vanadyl Sulfate In Drinking Water. Faseb Journal 1998, 12, 1289.
Sun, Y. ; Melchior, M. ; Summers, D. A. ; Thompson, R. C. ; Rettig, S. J. ; Orvig, C. [(Mu-Och3)Vo(Ma)](2), A Strongly Antiferromagnetic Oxovanadium(Iv) Dimer. Inorganic Chemistry 1998, 37, 3119-3121.
Setyawati, I. A. ; Thompson, K. H. ; Yuen, V. G. ; Sun, Y. ; Battell, M. ; Lyster, D. M. ; Vo, C. ; Ruth, T. J. ; Zeisler, S. ; McNeill, J. H. ; Orvig, C. Kinetic Analysis And Comparison Of Uptake, Distribution, And Excretion Of V-48-Labeled Compounds In Rats. Journal of Applied Physiology 1998, 84, 569-575.
Thaler, F. ; Hubbard, C. D. ; Heinemann, F. W. ; vanEldik, R. ; Schindler, S. ; Fabian, I. ; Dittler-Klingemann, A. M. ; Hahn, F. E. ; Orvig, C. Structural, Spectroscopic, Thermodynamic And Kinetic Properties Of Copper(Ii) Complexes With Tripodal Tetraamines. Inorganic Chemistry 1998, 37, 4022-4029.
Lowe, M. P. ; Caravan, P. ; Rettig, S. J. ; Orvig, C. Tightening The Hydrophobic Belt: Effects Of Backbone And Donor Group Variation On Podand Ligand Complexes Of The Lanthanides. Inorganic Chemistry 1998, 37, 1637-1647.
Hoveyda, H. R. ; Karunaratne, V. ; Nichols, C. J. ; Rettig, S. J. ; Stephens, A. K. W. ; Orvig, C. Tripodal Trisamides Based On Nicotinic And Picolinic Acid Derivatives. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1998, 76, 414-425.

1997

Thompson, K. H. ; Setyawati, I. ; Sun, Y. ; Yuen, V. ; Lyster, D. ; McNeill, J. H. ; Orvig, C. Kinetic Model Of Vanadium Metabolism In Rats. Comparison Of Organic And Inorganic Vanadium (Iv). Faseb Journal 1997, 11, 3479-3479.
Schonholzer, K. W. ; Sutton, R. A. L. ; Walker, V. R. ; Sossi, V. ; Schulzer, M. ; Orvig, C. ; Venczel, E. ; Johnson, R. R. ; Vetterli, D. ; DittrichHannen, B. ; Kubik, P. ; Suter, M. Intestinal Absorption Of Trace Amounts Of Aluminium In Rats Studied With (26)Aluminium And Accelerator Mass Spectrometry. Clinical Science 1997, 92, 379-383.
Yuen, V. G. ; Caravan, P. ; Gelmini, L. ; Glover, N. ; McNeill, J. H. ; Setyawati, I. A. ; Zhou, Y. ; Orvig, C. Glucose-Lowering Properties Of Vanadium Compounds: Comparison Of Coordination Complexes With Maltol Or Kojic Acid As Ligands. Journal of Inorganic Biochemistry 1997, 68, 109-116.
Caravan, P. ; Mehrkhodavandi, P. ; Orvig, C. Cationic Lanthanide Complexes Of N,n’-Bis(2-Pyridylmethyl)Ethylenediamine-N,n’-Diacetic Acid (H(2)Bped). Inorganic Chemistry 1997, 36, 1316-1321.
Caravan, P. ; Rettig, S. J. ; Orvig, C. Effect Of Pyridyl Donors In The Chelation Of Aluminum(Iii), Gallium(Iii), And Indium(Iii). Inorganic Chemistry 1997, 36, 1306-1315.
Caravan, P. ; Lowe, M. P. ; Read, P. W. ; Rettig, S. J. ; Yang, L. W. ; Orvig, C. Selectivity Among, And Aggregation Of, Lanthanide Ions. Journal of Alloys and Compounds 1997, 249, 49-51.
Yuen, V. G. ; Orvig, C. ; McNeill, J. H. Effects Of Bis(Maltolato)Oxovanadium(Iv) Are Distinct From Food Restriction In Stz-Diabetic Rats. American Journal of Physiology-Endocrinology and Metabolism 1997, 272, E30-E35.

1996

Yuen, V. G. ; Pederson, R. A. ; Dai, S. ; Orvig, C. ; McNeill, J. H. Effects Of Low And High Dose Administration Of Bis(Maltolato)Oxovanadium(Iv) On Fa/fa Zucker Rats. Canadian Journal of Physiology and Pharmacology 1996, 74, 1001-1009.
Lowe, M. P. ; Rettig, S. J. ; Orvig, C. Highly Symmetric Group 13 Metal-Phosphinato Complexes: Multinuclear Nmr (Al-27, P-31, Ga-71) Determination Of Stability Constants At Low Ph. Journal of the American Chemical Society 1996, 118, 10446-10456.
Luo, H. Y. ; Orvig, C. Rhenium Complexes Of P,p,p’,p’-Tetrakis(O-Hydroxyphenyl)Diphosphinoethane. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1996, 74, 722-729.
Sun, Y. ; James, B. R. ; Rettig, S. J. ; Orvig, C. Oxidation Kinetics Of The Potent Insulin Mimetic Agent Bis(Maltolato)Oxovanadium(Iv) (Bmov) In Water And In Methanol. Inorganic Chemistry 1996, 35, 1667-1673.
Luo, H. Y. ; Orvig, C. ; Rettig, S. J. Trans-Tetrachlorobis(Triphenylphosphine-P)-Rhenium(Iv)-Mer-Trans-Trichlo Rooxobis(Triphenylphosphine-P)Rhenium(V) (0.86/0.14). Acta Crystallographica Section C-Crystal Structure Communications 1996, 52, 1377-1380.
Shuter, E. ; Hoveyda, H. R. ; Karunaratne, V. ; Rettig, S. J. ; Orvig, C. Bis(Ligand) Rhenium(V) And Technetium(V) Complexes Of Two Naturally Occurring Binding Moieties (Oxazoline And Thiazoline). Inorganic Chemistry 1996, 35, 368-372.
Wong, E. ; Caravan, P. ; Liu, S. ; Rettig, S. J. ; Orvig, C. Selectivity Of Potentially Hexadentate Amine Phenols For Ga3+ And In3+ In Aqueous Solution. Inorganic Chemistry 1996, 35, 715-724.
DittlerKlingemann, A. M. ; Orvig, C. ; Hahn, F. E. ; Thaler, F. ; Hubbard, C. D. ; vanEldik, R. ; Schindler, S. ; Fabian, I. Geometric Factors In The Structural And Thermodynamic Properties Of Copper(Ii) Complexes With Tripodal Tetraamines. Inorganic Chemistry 1996, 35, 7798-7803.
DittlerKlingemann, A. M. ; Hahn, F. E. ; Orvig, C. ; Rettig, S. J. (Acetonitrile)[N,n-Bis(3-Aminopropyl)-1,3-Propanediamine-N,n’,n’’,n’’’]C Opper(Ii) Diperchlorate. Acta Crystallographica Section C-Crystal Structure Communications 1996, 52, 1957-1959.
Harris, W. R. ; Berthon, G. ; Day, J. P. ; Exley, C. ; Flaten, T. P. ; Forbes, W. F. ; Kiss, T. ; Orvig, C. ; Zatta, P. F. Speciation Of Aluminum In Biological Systems. Journal of Toxicology and Environmental Health 1996, 48, 543-568.

1995

Yuen, V. G. ; Orvig, C. ; McNeill, J. H. Comparison Of The Glucose-Lowering Properties Of Vanadyl Sulfate And Bis(Maltolato)Oxovanadium(Iv) Following Acute And Chronic Administration. Canadian Journal of Physiology and Pharmacology 1995, 73, 55-64.
Wong, E. ; Liu, S. ; Lugger, T. ; Hahn, F. E. ; Orvig, C. Hexadentate N4O2 Amine Phenol Complexes Of Gallium And Indium. Inorganic Chemistry 1995, 34, 93-101.
Shuter, E. ; Rettig, S. J. ; Orvig, C. Oxobis(2,4-Pentanedionato)Vanadium(Iv), A Redetermination. Acta Crystallographica Section C-Crystal Structure Communications 1995, 51, 12-14.
McNeill, J. H. ; Yuen, V. G. ; Dai, S. T. ; Orvig, C. Increased Potency Of Vanadium Using Organic Ligands. Molecular and Cellular Biochemistry 1995, 153, 175-180.
Caravan, P. ; Gelmini, L. ; Glover, N. ; Herring, F. G. ; Li, H. L. ; McNeill, J. H. ; Rettig, S. J. ; Setyawati, I. A. ; Shuter, E. ; Sun, Y. ; Tracey, A. S. ; Yuen, V. G. ; Orvig, C. Reaction Chemistry Of Bmov, Bis(Maltolato)Oxovanadium(Iv) - A Potent Insulin Mimetic Agent. Journal of the American Chemical Society 1995, 117, 12759-12770.
Luo, H. Y. ; Liu, S. ; Rettig, S. J. ; Orvig, C. Rhenium And Technetium Complexes From Pentadentate (N3O2) And Tetradentate (N2O2) Schiff Base Ligands. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1995, 73, 2272-2281.
Yang, L. W. ; Liu, S. ; Wong, E. ; Rettig, S. J. ; Orvig, C. Complexes Of Trivalent Metal-Ions With Potentially Heptadentate N4O3 Schiff-Base And Amine Phenol Ligands Of Varying Rigidity. Inorganic Chemistry 1995, 34, 2164-2178.
Allen, D. D. ; Orvig, C. ; Yokel, R. A. Evidence For Energy-Dependent Transport Of Aluminum Out Of Brain Extracellular Fluid. Toxicology 1995, 98, 31-39.
Luo, H. Y. ; Setyawati, I. ; Rettig, S. J. ; Orvig, C. Rhenium(V) And Technetium(V) Complexes Of Bis(O-Hydroxyphenyl)Phenylphosphine (Po2(2-)) And (O-Hydroxyphenyl)Diphenylphosphine (Po-) Ligands. Inorganic Chemistry 1995, 34, 2287-2299.
Orvig, C. ; Thompson, K. H. ; Battell, M. ; McNeill, J. H. Vanadium Compounds As Insulin Mimics. In Metal Ions in Biological Systems, Vol 31; Metal Ions in Biological Systems, Vol 31; Marcel Dekker: New York, 1995; Vol. 31, pp. 575-594.
Wong, E. ; Liu, S. ; Rettig, S. J. ; Orvig, C. Gallium And Indium Complexes Of Hexadentate Ligands Containing Pendant Pyridyl And Phenolate Groups. Inorganic Chemistry 1995, 34, 3057-3064.

1994

Allen, D. D. ; Orvig, C. ; Yokel, R. A. Pharmacokinetics And Distribution Of Tris(Maltolato)Aluminum(Iii) Into The Central-Nervous-System. Neurotoxicology 1994, 15, 371-378.
Orvig, C. ; Rettig, S. J. ; Zhang, Z. H. 1-Carboxymethyl-3-Hydroxy-2-Methyl-4(1H)-Pyridinone (Monoclinic Form-2). Acta Crystallographica Section C-Crystal Structure Communications 1994, 50, 1511-1514.
Edwards, D. S. ; Liu, S. ; Poirier, M. J. ; Zhang, Z. H. ; Webb, G. A. ; Orvig, C. Characterization Of Tris(N-Substituted-2-Methyl-3-Hydroxy-4-Pyridinonato)Technetium(Iv) Cations. Inorganic Chemistry 1994, 33, 5607-5609.
Lutz, T. G. ; Clevette, D. J. ; Hoveyda, H. R. ; Karunaratne, V. ; Nordin, A. ; Sjoberg, S. ; Winter, M. ; Orvig, C. Preparation Of 2-Substituted And 4-Substituted 3-Hydroxy-5-Methylfurans And The Aluminum And Gallium Complexes Of 3-Hydroxy-5-Methyl-2-(N-Methylformamido)Furan. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1994, 72, 1362-1369.
Hoveyda, H. R. ; Orvig, C. ; Rettig, S. J. Mer-Tris[2-(5-Bromo-2-Hydroxyphenyl)-2-Oxazolinato]Aluminium(Iii) Methanol Solvate. Acta Crystallographica Section C-Crystal Structure Communications 1994, 50, 1906-1909.

1993

Edwards, D. S. ; Liu, S. N. ; Lyster, D. M. ; Poirier, M. J. ; Vo, C. ; Webb, G. A. ; Zhang, Z. H. ; Orvig, C. Potential Tc-99M Radiopharmaceuticals For Renal Imaging - Tris(N-Substituted-3-Hydroxy-2-Methyl-4-Pyridinonato)Technetium(Iv) Cations. Nuclear Medicine and Biology 1993, 20, 857-863.
Yuen, V. G. ; Orvig, C. ; McNeill, J. H. Glucose-Lowering Effects Of A New Organic Vanadium Complex, Bis(Maltolato)Oxovanadium(Iv). Canadian Journal of Physiology and Pharmacology 1993, 71, 263-269.
Yuen, V. G. ; Orvig, C. ; Thompson, K. H. ; McNeill, J. H. Improvement In Cardiac Dysfunction In Streptozotocin-Induced Diabetic Rats Following Chronic Oral-Administration Of Bis(Maltolato)Oxovanadium(Iv). Canadian Journal of Physiology and Pharmacology 1993, 71, 270-276.

1992

Zhang, Z. H. ; Lyster, D. M. ; Webb, G. A. ; Orvig, C. Potential Ga-67 Radiopharmaceuticals For Myocardial Imaging - Tris(1-Aryl-3-Hydroxy-2-Methyl-4-Pyridinonato)Gallium(Iii) Complexes. Nuclear Medicine and Biology 1992, 19, 327-335.
Karunaratne, V. ; Hoveyda, H. R. ; Orvig, C. General-Method For The Synthesis Of Trishydroxamic Acids. Tetrahedron Letters 1992, 33, 1827-1830.
Zhang, Z. H. ; Rettig, S. J. ; Orvig, C. Physical And Structural Studies Of N-Carboxymethyl-3-Hydroxy-2-Methyl-4-Pyridinone And N-(Para-Methoxyphenyl)-3-Hydroxy-2-Methyl-4-Pyridinone. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1992, 70, 763-770.
Hoveyda, H. R. ; Karunaratne, V. ; Orvig, C. Design And Synthesis Of Multidentate 2-(2’-Hydroxyphenyl)-2-Thiazolines For Biomedical Application. Tetrahedron 1992, 48, 5219-5226.
Liu, S. ; Gelmini, L. ; Rettig, S. J. ; Thompson, R. C. ; Orvig, C. Synthesis And Characterization Of Lanthanide [Ln(L)]2 Complexes Of N4O3 Amine Phenol Ligands With Phenolate Oxygen Bridges - Evidence For Very Weak Magnetic Exchange Between Lanthanide Ions. Journal of the American Chemical Society 1992, 114, 6081-6087.
McNeill, J. H. ; Yuen, V. G. ; Hoveyda, H. R. ; Orvig, C. Bis(Maltolato)Oxovanadium(Iv) Is A Potent Insulin Mimic. Journal of Medicinal Chemistry 1992, 35, 1489-1491.

1991

Simpson, L. ; Rettig, S. J. ; Trotter, J. ; Orvig, C. 1-Normal-Propyl-3-Hydroxy-2-Methyl-4-Pyridinone And 1-Normal-Butyl-3-Hydroxy-2-Methyl-4-Pyridinone Complexes Of Group 13 (Iiia) Metal-Ions. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1991, 69, 893-900.
Zhang, Z. H. ; Rettig, S. J. ; Orvig, C. Lipophilic Coordination-Compounds - Aluminum, Gallium, And Indium Complexes Of 1-Aryl-3-Hydroxy-2-Methyl-4-Pyridinones. Inorganic Chemistry 1991, 30, 509-515.

1990

Orvig, C. ; Rettig, S. J. ; Trotter, J. ; Zhang, Z. H. Structural Studies Of Organoboron Compounds .41. (3-Hydroxy-2-Methyl-1-(Para-Tolyl)-4-Pyridinonato)Diphenylboron. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1990, 68, 1803-1807.
Clevette, D. J. ; Lyster, D. M. ; Nelson, W. O. ; Rihela, T. ; Webb, G. A. ; Orvig, C. Solution Chemistry Of Gallium And Indium 3-Hydroxy-4-Pyridinone Complexes Invitro And Invivo. Inorganic Chemistry 1990, 29, 667-672.

1989

Zhang, Z. H. ; Hui, T. L. T. ; Orvig, C. One-Pot Synthesis Of N-Substituted-3-Hydroxy-4-Pyridinone Chelate Complexes Of Aluminum, Gallium, And Indium. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1989, 67, 1708-1710.
Clevette, D. J. ; Nelson, W. O. ; Nordin, A. ; Orvig, C. ; Sjoberg, S. Equilibrium And Structural Studies Of Silicon(Iv) And Aluminum(Iii) In Aqueous-Solution .18. Complexation Of Aluminum With N-Substituted 3-Hydroxy-4-Pyridinones. Inorganic Chemistry 1989, 28, 2079-2081.
Lutz, T. G. ; Clevette, D. J. ; Rettig, S. J. ; Orvig, C. Metal Chelation With Natural-Products - Isomaltol Complexes Of Aluminum, Gallium, And Indium. Inorganic Chemistry 1989, 28, 715-719.
Nelson, W. O. ; Rettig, S. J. ; Orvig, C. Aluminum And Gallium Complexes Of 1-Ethyl-3-Hydroxy-2-Methyl-4-Pyridinone - A New Exoclathrate Matrix. Inorganic Chemistry 1989, 28, 3153-3157.

1988

Nelson, W. O. ; Orvig, C. ; Rettig, S. J. ; Trotter, J. Structural Studies Of Organoboron Compounds .27. (3-Hydroxy-2-Methyl-4-Pyridinonato)Diphenylboron And (3-Hydroxy-1,2-Dimethyl-4-Pyridinonato)Diphenylboron. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1988, 66, 132-138.
Matsuba, C. A. ; Rettig, S. J. ; Orvig, C. Main Group (Iiia Or 13) Complexes Of Benzohydroxamic Acid And The Crystal-Structure Of Tris(Benzohydroxamato)Indium(Iii). Canadian Journal of Chemistry-Revue Canadienne De Chimie 1988, 66, 1809-1813.
Matsuba, C. A. ; Nelson, W. O. ; Rettig, S. J. ; Orvig, C. Neutral Water-Soluble Indium Complexes Of 3-Hydroxy-4-Pyrones And 3-Hydroxy-4-Pyridinones. Inorganic Chemistry 1988, 27, 3935-3939.
Nelson, W. O. ; Karpishin, T. B. ; Rettig, S. J. ; Orvig, C. Physical And Structural Studies Of N-Substituted-3-Hydroxy-2-Methyl-4(1H)-Pyridinones. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1988, 66, 123-131.

1987

Orvig, C. ; Rettig, S. J. ; Trotter, J. Structural Studies Of Organoboron Compounds .25. Synthesis And Structure Of (Maltolato)Diphenylboron. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1987, 65, 590-594.
Orvig, C. ; Nelson, W. O. ; Rettig, S. J. N-Substituted-Hydroxypyridinone Complexes Of Al And Ga. Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society 1987, 106, 405-405.
Nelson, W. O. ; Rettig, S. J. ; Orvig, C. The Exoclathrate Al(C7H8No2)3.12H2O - A Facial Geometry Imposed By Extensive Hydrogen-Bonding With The Ice-I Structure. Journal of the American Chemical Society 1987, 109, 4121-4123.
Finnegan, M. M. ; Lutz, T. G. ; Nelson, W. O. ; Smith, A. ; Orvig, C. Neutral Water-Soluble Post-Transition-Metal Chelate Complexes Of Medical Interest - Aluminum And Gallium Tris(3-Hydroxy-4-Pyronates). Inorganic Chemistry 1987, 26, 2171-2176.

1986

Finnegan, M. M. ; Rettig, S. J. ; Orvig, C. A Neutral Water-Soluble Aluminum Complex Of Neurological Interest. Journal of the American Chemical Society 1986, 108, 5033-5035.