Research & Teaching Faculty

  1. Research & Teaching Faculty
  2. Department Publications
  3. Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III)

Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III)

TitleCarbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III)
Publication TypeJournal Article
Year of Publication2005
AuthorsGreen, DE, Ferreira, CL, Stick, RV, Patrick, BO, Adam, MJ, Orvig, C
JournalBioconjugate Chemistry
Volume16
Pagination1597-1609
Date PublishedNov-Dec
Type of ArticleArticle
ISBN Number1043-1802
Keywordsaluminum, ANALOGS, CITRATE, GLUCOSE, INVIVO, SYSTEM, TC-99M
Abstract

Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing 3-hydroxy-4-pyridinone ligand precursors and their tris(ligand)gallium(III) and -indium(III) complexes were synthesized and characterized by mass spectrometry, elemental analysis, and H-1 and C-13 NMR spectroscopy, and in the case of one intermediate, by X-ray crystallography. With three equivalents of ligand, neutral complexes formed with the bidentate hydroxypyridinone moiety complexing the gallium(III) and indium(III) metal centers.
URL<Go to ISI>://000233393800036