| Title | Rearmed Bifunctional Chelating Ligand for 225Ac/155Tb Precision-Guided Theranostic Radiopharmaceuticals─H4noneunpaX |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Wharton, L, Yang, H, Jaraquemada-Pelaez, Mde Guadalu, Merkens, H, Engudar, G, Ingham, A, Koniar, H, Radchenko, V, Kunz, P, Schaffer, P, Bénard, F, Orvig, C |
| Journal | J. Med. Chem. |
| Volume | 66 |
| Pagination | 13705-13730. Invited for Virtual Special Issue “Diagnostic and Therapeutic Radiopharmaceuticals” |
| Date Published | 09/2023 |
| Abstract | { Superior bifunctional chelating ligands, which can sequester both α-emitting radionuclides (225Ac, 213Bi) and their diagnostic companions (155Tb, 111In), remain a formidable challenge to translating targeted alpha therapy, with complementary diagnostic imaging, to the clinic. H4noneupaX, a chelating ligand with an unusual diametrically opposed arrangement of pendant donor groups, has been developed to this end. H4noneunpaX preferentially complexes Ln3+ and An3+ ions, forming thermodynamically stable (pLa = 17.8 |
| URL | https://doi.org/10.1021/acs.jmedchem.3c01151 |
| DOI | 10.1021/acs.jmedchem.3c01151 |
| Refereed Designation | Refereed |
