| Title | Novel “bi-modal” H2dedpa derivatives for radio- and fluorescence imaging |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Ramogida, CF, Murphy, L, Cawthray, JF, Ross, JD, Adam, MJ, Orvig, C |
| Journal | J. Inorg. Biochem. |
| Volume | 162 |
| Pagination | 253 - 262 |
| ISSN | 0162-0134 |
| Keywords | Spheroids |
| Abstract | Abstract A novel pyridyl functionalized analog of the promising hexadentate 68Ga3 + chelate \{H2dedpa\} (N4O2, 1,2-[[6-carboxy-pyridin-2-yl]-methylamine]ethane) was successfully synthesized and characterized. This new bifunctional chelate (BFC) was used to prepare the first proof-of-principle bi-modal \{H2dedpa\} derivative for fluorescence and nuclear imaging. Two bi-modal \{H2dedpa\} derivatives were prepared: H2dedpa-propylpyr-FITC and H2dedpa-propylpyr-FITC-(N,N′-propyl-2-NI) (FITC = fluorescei |
| URL | http://www.sciencedirect.com/science/article/pii/S0162013415301239 |
| DOI | 10.1016/j.jinorgbio.2015.11.021 |
| Refereed Designation | Refereed |
