| Title | Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Mikata, Y, Shinohara, Y, Yoneda, K, Nakamura, Y, Brudzinska, I, Tanase, T, Kitayama, T, Takagi, R, Okamoto, T, Kinoshita, I, Doe, M, Orvig, C, Yano, S |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 11 |
| Pagination | 3045-3047 |
| Date Published | Dec |
| Type of Article | Article |
| ISBN Number | 0960-894X |
| Keywords | CISPLATIN, DNA, DRUGS, MOLECULES |
| Abstract | Eight carbohydrate-pendant platinum(II) complexes have been synthesized from carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xylose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the carbohydrate moieties reduced the toxicity inherent with platinum(II) complexes. (C) 2001 Elsevier Science Ltd. All rights reserved. |
| URL | <Go to ISI>://000172267600013 |
