@article {doi:10.1021/acs.inorgchem.1c02709,
	title = {[nat/89Zr][Zr(pypa)]: Thermodynamically Stable and Kinetically Inert Binary Nonadentate Complex for Radiopharmaceutical Applications},
	journal = {Inorg. Chem.},
	volume = {60},
	year = {2021},
	month = {11/2021},
	pages = {18082-18093},
	abstract = {<p>{ H4pypa is a nonadentate nonmacrocyclic chelator, which previously demonstrated high affinity for scandium-44, lutetium-177, and indium-111. Herein, we report the highly stable binary [Zr(pypa)] complex; the nonradioactive complex was synthesized and characterized in detail using high-resolution electrospray-ionization mass spectroscopy (HR-ESI-MS) and various nuclear magnetic resonance spectroscopies (NMR), which revealed C2v symmetry of the complex. The geometry of [Zr(pypa)] was further detailed via X-ray crystallography and compared with the structure of [Fe(Hpypa)]. Despite a slow complexation rate with an association half-life of 31.4 h at pH 2 and room temperature, the [Zr(pypa)] complex is thermodynamically stable (log KML = 38.92</p>},
	doi = {10.1021/acs.inorgchem.1c02709},
	url = {https://doi.org/10.1021/acs.inorgchem.1c02709},
	author = {Southcott, Lily and LI, LILY and Patrick, Brian O. and Stephan, Holger and Jaraquemada-Pelaez, Maria de Guadalupe and Orvig, Chris}
}
