@article {doi:10.1021/acs.inorgchem.1c02709, title = {[nat/89Zr][Zr(pypa)]: Thermodynamically Stable and Kinetically Inert Binary Nonadentate Complex for Radiopharmaceutical Applications}, journal = {Inorg. Chem.}, volume = {60}, year = {2021}, month = {11/2021}, pages = {18082-18093}, abstract = {

{ H4pypa is a nonadentate nonmacrocyclic chelator, which previously demonstrated high affinity for scandium-44, lutetium-177, and indium-111. Herein, we report the highly stable binary [Zr(pypa)] complex; the nonradioactive complex was synthesized and characterized in detail using high-resolution electrospray-ionization mass spectroscopy (HR-ESI-MS) and various nuclear magnetic resonance spectroscopies (NMR), which revealed C2v symmetry of the complex. The geometry of [Zr(pypa)] was further detailed via X-ray crystallography and compared with the structure of [Fe(Hpypa)]. Despite a slow complexation rate with an association half-life of 31.4 h at pH 2 and room temperature, the [Zr(pypa)] complex is thermodynamically stable (log KML = 38.92

}, doi = {10.1021/acs.inorgchem.1c02709}, url = {https://doi.org/10.1021/acs.inorgchem.1c02709}, author = {Southcott, Lily and LI, LILY and Patrick, Brian O. and Stephan, Holger and Jaraquemada-Pelaez, Maria de Guadalupe and Orvig, Chris} }