Valery Radchenko

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Valery Radchenko

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Research and Teaching Interests

The increasing incidence of cancer worldwide is pushing clinicians and researchers to broaden and improve the available diagnostic and treatment arsenal. The use of radionuclides in medical imaging and therapy has a long history of research and application. Developing new and more efficient ways to produce medical radionuclides has become a very important task due to the increasing need for novel radiopharmaceuticals. Accelerator production of medical radionuclides along with reactor production are two main routes. Usually after production, medical radionuclides require radiochemical purification for further pre-clinical and clinical application. TRIUMF is a national and international hub for the production of many medical radionuclides for imaging and therapy of cancer. TRIUMF operates several cyclotrons which are currently utilized for various purposes (including medical isotope production). TRIUMF also operates one of the largest cyclotrons in the world with 500 MeV proton energy; this particle accelerator could enable the production of many novel radionuclides for nuclear medicine.

Our goal is to create effective therapeutic radiopharmaceuticals based on alpha (e. g. 225Ac/213Bi,227Th, 223Ra) and auger (119Sb, 125I,103mRh) emitting radionuclides as well to expand our imaging “toolbox” with additional radionuclides with various half-lives (e.g. 44Sc,90Nb, 89Zr). 

There is an immediate thesis opportunity jointly with Prof. Chris Orvig (https://orvig.chem.ubc.ca)  to join the dynamic and fast-growing Life Sciences group at TRIUMF and work on various aspects of the production of medical radionuclides for imaging and therapy, as well as be involved in the testing and application of radiopharmaceuticals based on these radionuclides with national and international partners.

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TRIUMF
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+1 604 222 7527

Curriculum Vitae

Dr. Valery Radchenko is a research scientist at TRIUMF and adjunct professor at UBC Chemistry with a primary research focus on production and application of therapeutic radionuclides for Targeted Radionuclide Therapy (TRT). Dr. Radchenko is a radiochemist by training, and graduated from Saint-Petersburg State Technical University (Russian Federation) in collaboration with Joint Institute for Nuclear Research (JINR) in Dubna (Russian Federation). He received his PhD from Johannes-Gutenberg University Mainz (Germany) in 2013 with a thesis focused on design of production of promising radionuclide for immuno-PET: 90Nb. In realizing the potential of targeted therapy, Dr. Radchenko pursued a postdoctoral position at Los Alamos National Laboratory (LANL) in New Mexico, USA, where he worked as a part of tri-lab effort on production of 225Ac from spallation of thorium with high energy protons. In addition to 225Ac production, he also worked on other efforts including extraction of valuable medical radionuclides from irradiated thorium targets, such as 223/224/225Ra, 230Pa, 103Ru/103mRh and 111Ag, while also testing production of alternative candidates for low energy (≤ 35 MeV) slot  at LANL Isotopes Production Facility  (44Ti/44Sc and 119Sb). To date, Valery has published over 30 scientific papers in peer-reviewed journals and was guest editor on several special issues about medical radionuclides

Publications

2018

Mastren, T. ; Radchenko, V. ; Engle, J. W. ; Weidner, J. W. ; Owens, A. ; Wyant, L. E. ; Copping, R. ; Brugh, M. ; F. Nortier, M. ; Birnbaum, E. R. ; John, K. D. ; Fassbender, M. E. Chromatographic Separation Of The Theranostic Radionuclide 111Ag From A Proton Irradiated Thorium Matrix. Analytica Chimica Acta 2018, 998, 75 - 82.
Robertson, A. K. H. ; Ramogida, C. Fortunata; Schaffer, P. ; Radchenko, V. Development Of 225Ac Radiopharmaceuticals: Triumf Perspectives And Experiences. In Current radiopharmaceuticals; Current radiopharmaceuticals; 2018.
Inoyatov, А. K. ; Kovalík, A. ; Perevoshchikov, L. L. ; Filosofov, D. V. ; Ekman, J. ; Vénos, D. ; Muminov, T. M. ; Radchenko, V. ; Zhdanov, V. S. The Experimental Investigation Of Weak Effects In The Kll Auger Electron Spectrum Of Zr And Nb Generated In Radioactive Decay. Journal of Electron Spectroscopy and Related Phenomena 2018, 229, 61 - 67.
de la Fuente, A. ; Radchenko, V. ; Tsotakos, T. ; Tsoukalas, C. ; Paravatou-Petsotas, M. ; Harris, A. L. ; Köster, U. ; Rösch, F. ; Bouziotis, P. Conjugation, Labelling And In Vitro/in Vivo Assessment Of An Anti-Vegf Monoclonal Antibody Labelled With Niobium Isotopes. Journal of Radioanalytical and Nuclear Chemistry 2018, 318, 1991–1997.
Mastren, T. ; Stein, B. W. ; T. Parker, G. ; Radchenko, V. ; Copping, R. ; Owens, A. ; Wyant, L. E. ; Brugh, M. ; Kozimor, S. A. ; F. Nortier, M. ; Birnbaum, E. R. ; John, K. D. ; Fassbender, M. E. Separation Of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins. Analytical Chemistry 2018, 90, 7012-7017.
Baimukhanova, A. ; Radchenko, V. ; Kozempel, J. ; Marinova, A. ; Brown, V. ; Karandashev, V. ; Karaivanov, D. ; Schaffer, P. ; Filosofov, D. Utilization Of (P, 4N) Reaction For 86Zr Production With Medium Energy Protons And Development Of A 86Zr → 86Y Radionuclide Generator. Journal of Radioanalytical and Nuclear Chemistry 2018, 316, 191–199.

2017

Hoehr, C. ; Bénard, F. ; Buckley, K. ; Crawford, J. ; Gottberg, A. ; Hanemaayer, V. ; Kunz, P. ; Ladouceur, K. ; Radchenko, V. ; Ramogida, C. ; Robertson, A. ; Ruth, T. ; Zacchia, N. ; Zeisler, S. ; Schaffer, P. Medical Isotope Production At Triumf – From Imaging To Treatment. Physics Procedia 2017, 90, 200 - 208.
Mastren, T. ; Radchenko, V. ; Hopkins, P. D. ; Engle, J. W. ; Weidner, J. W. ; Copping, R. ; Brugh, M. ; F. Nortier, M. ; Birnbaum, E. R. ; John, K. D. ; Fassbender, M. Ernst- Hein Separation Of 103Ru From A Proton Irradiated Thorium Matrix: A Potential Source Of Auger Therapy Radionuclide 103Mrh. PLOS ONE 2017, 12, 1-10.
Thiele, N. A. ; Brown, V. ; Kelly, J. M. ; Amor-Coarasa, A. ; Jermilova, U. ; MacMillan, S. N. ; Nikolopoulou, A. ; Ponnala, S. ; Ramogida, C. F. ; Robertson, A. K. H. ; Rodríguez-Rodríguez, C. ; Schaffer, P. ; Jr., C. Williams; Babich, J. W. ; Radchenko, V. ; Wilson, J. J. An Eighteen-Membered Macrocyclic Ligand For Actinium-225 Targeted Alpha Therapy. Angewandte Chemie International Edition 2017, 56, 14712-14717.
Radchenko, V. ; Mastren, T. ; Meyer, C. A. L. ; Ivanov, A. S. ; Bryantsev, V. S. ; Copping, R. ; Denton, D. ; Engle, J. W. ; Griswold, J. R. ; Murphy, K. ; Wilson, J. J. ; Owens, A. ; Wyant, L. ; Birnbaum, E. R. ; Fitzsimmons, J. ; Medvedev, D. ; Cutler, C. S. ; Mausner, L. F. ; Nortier, M. F. ; John, K. D. ; Mirzadeh, S. ; Fassbender, M. E. Radiometric Evaluation Of Diglycolamide Resins For The Chromatographic Separation Of Actinium From Fission Product Lanthanides. Talanta 2017, 175, 318 - 324.
Radchenko, V. ; Engle, J. W. ; Medvedev, D. G. ; Maassen, J. M. ; Naranjo, C. M. ; Unc, G. A. ; Meyer, C. A. L. ; Mastren, T. ; Brugh, M. ; Mausner, L. ; Cutler, C. S. ; Birnbaum, E. R. ; John, K. D. ; F. Nortier, M. ; Fassbender, M. E. Proton-Induced Production And Radiochemical Isolation Of 44Ti From Scandium Metal Targets For 44Ti/44Sc Generator Development. Nuclear Medicine and Biology 2017, 50, 25 - 32.
Mastren, T. ; Radchenko, V. ; Bach, H. T. ; Balkin, E. R. ; Birnbaum, E. R. ; Brugh, M. ; Engle, J. W. ; Gott, M. D. ; Guthrie, J. ; Hennkens, H. M. ; John, K. D. ; Ketring, A. R. ; Kuchuk, M. ; Maassen, J. R. ; Naranjo, C. M. ; F. Nortier, M. ; Phelps, T. E. ; Jurisson, S. S. ; D. Wilbur, S. ; Fassbender, M. E. Bulk Production And Evaluation Of High Specific Activity 186Gre For Cancer Therapy Using Enriched 186Wo3 Targets In A Proton Beam. Nuclear Medicine and Biology 2017, 49, 24 - 29.
Mastren, T. ; Radchenko, V. ; Owens, A. ; Copping, R. ; Boll, R. ; Griswold, J. ; Mirzadeh, S. ; Wyant, L. E. ; Brugh, M. ; Engle, J. W. ; Nortier, F. Meiring; Birnbaum, E. R. ; K. John, D. ; Fassbender, M. Ernst- Hein Simultaneous Separation Of Actinium And Radium Isotopes From A Proton Irradiated Thorium Matrix. In Scientific Reports; Scientific Reports; 2017.
Thiabaud, G. ; Radchenko, V. ; Wilson, J. J. ; John, K. D. ; Birnbaum, E. R. ; Sessler, J. L. Rapid Insertion Of Bismuth Radioactive Isotopes Into Texaphyrin In Aqueous Media. Journal of Porphyrins and Phthalocyanines 2017, 21, 882-886.

2016

Radchenko, V. ; Meyer, C. A. L. ; Engle, J. W. ; Naranjo, C. M. ; Unc, G. A. ; Mastren, T. ; Brugh, M. ; Birnbaum, E. R. ; John, K. D. ; Nortier, F. M. ; Fassbender, M. E. Separation Of 44Ti From Proton Irradiated Scandium By Using Solid-Phase Extraction Chromatography And Design Of 44Ti/44Sc Generator System. Journal of Chromatography A 2016, 1477, 39 - 46.
Griswold, J. R. ; Medvedev, D. G. ; Engle, J. W. ; Copping, R. ; Fitzsimmons, J. M. ; Radchenko, V. ; Cooley, J. C. ; Fassbender, M. E. ; Denton, D. L. ; Murphy, K. E. ; Owens, A. C. ; Birnbaum, E. R. ; John, K. D. ; Nortier, F. M. ; Stracener, D. W. ; Heilbronn, L. H. ; Mausner, L. F. ; Mirzadeh, S. Large Scale Accelerator Production Of 225Ac: Effective Cross Sections For 78–192Mev Protons Incident On 232Th Targets. Applied Radiation and Isotopes 2016, 118, 366 - 374.
Radchenko, V. ; Bouziotis, P. ; Tsotakos, T. ; Paravatou-Petsotas, M. ; de la Fuente, A. ; Loudos, G. ; Harris, A. L. ; Xanthopoulos, S. ; Filosofov, D. ; Hauser, H. ; Eisenhut, M. ; Ponsard, B. ; Roesch, F. Labeling And Preliminary In Vivo Assessment Of Niobium-Labeled Radioactive Species: A Proof-Of-Concept Study. Nuclear Medicine and Biology 2016, 43, 280 - 287.

2015

Filosofov, D. V. ; Lebedev, N. A. ; Radchenko, V. ; Rakhimov, A. V. ; Happel, S. ; Roesch, F. Behavior Of Actinium, Alkaline, And Rare Earth Elements In Sr-Resin/mineral Acid Systems. Solvent Extraction and Ion Exchange 2015, 33, 496-509.
Radchenko, V. ; Engle, J. W. ; Wilson, J. J. ; Maassen, J. R. ; Nortier, F. M. ; Taylor, W. A. ; Birnbaum, E. R. ; Hudston, L. A. ; John, K. D. ; Fassbender, M. E. Application Of Ion Exchange And Extraction Chromatography To The Separation Of Actinium From Proton-Irradiated Thorium Metal For Analytical Purposes. Journal of Chromatography A 2015, 1380, 55 - 63.
Wilson, J. J. ; Ferrier, M. ; Radchenko, V. ; Maassen, J. R. ; Engle, J. W. ; Batista, E. R. ; Martin, R. L. ; Nortier, F. M. ; Fassbender, M. E. ; John, K. D. ; Birnbaum, E. R. Evaluation Of Nitrogen-Rich Macrocyclic Ligands For The Chelation Of Therapeutic Bismuth Radioisotopes. Nuclear Medicine and Biology 2015, 42, 428 - 438.

2014

2011

Inoyatov, A. K. ; Perevoshchikov, L. L. ; Gorozhankin, V. M. ; Kovalík, A. ; Radchenko, V. I. ; Filosofov, D. V. Searching For Influence Of The “Atomic Structure Effect” On The Kll And Lmm Auger Transition Energies Of Zn (Z=30) And Gd (Z=64). Journal of Electron Spectroscopy and Related Phenomena 2011, 184, 457 - 462.