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Templation in the formation of carceplexes

TitleTemplation in the formation of carceplexes
Publication TypeJournal Article
Year of Publication1998
AuthorsChapman, RG, Sherman, JC
JournalJournal of Organic Chemistry
Date PublishedJun
Type of ArticleArticle
ISBN Number0022-3263

The formation of carceplexes and hemicarceplexes involves an assembly process whereby a molecular template is entrapped between two bowl-shaped molecules. The process can be highly selective such that a million-fold range in template recognition has been realized. The relative template abilities, or template ratios, for 34 molecules in forming carceplex a guest is described. Species with one, two, and three bridges linking the two "bowls" are reported and were used to delineate the guest-determining step of the reaction. The effect of base and solvent on the reaction are also described, and a discussion of the reaction mechanism is presented.

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