Title | Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Wrodnigg, TM, Diness, F, Gruber, C, Hausler, H, Lundt, I, RUPITZ, K, Steiner, AJ, Stutz, AE, Tarling, CA, Withers, SG, Wolfler, H |
Journal | BIOORGANIC & MEDICINAL CHEMISTRY |
Volume | 12 |
Pagination | 3485-3495 |
Date Published | JUL 1 |
ISSN | 0968-0896 |
Abstract | A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the beta-glucosidase from Agrobacterium sp. K-i values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/ inhibitor binding. (C) 2004 Elsevier Ltd. All rights reserved. |
DOI | 10.1016/j.bmc.2004.04.037 |
