|Title||Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Wrodnigg, TM, Diness, F, Gruber, C, Hausler, H, Lundt, I, RUPITZ, K, Steiner, AJ, Stutz, AE, Tarling, CA, Withers, SG, Wolfler, H|
|Journal||BIOORGANIC & MEDICINAL CHEMISTRY|
|Date Published||JUL 1|
A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the beta-glucosidase from Agrobacterium sp. K-i values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/ inhibitor binding. (C) 2004 Elsevier Ltd. All rights reserved.