@article { ISI:000222195900007, title = {Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors}, journal = {BIOORGANIC \& MEDICINAL CHEMISTRY}, volume = {12}, number = {13}, year = {2004}, month = {JUL 1}, pages = {3485-3495}, abstract = {A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the beta-glucosidase from Agrobacterium sp. K-i values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/ inhibitor binding. (C) 2004 Elsevier Ltd. All rights reserved.}, issn = {0968-0896}, doi = {10.1016/j.bmc.2004.04.037}, author = {Wrodnigg, TM and Diness, F and Gruber, C and Hausler, H and Lundt, I and RUPITZ, K and Steiner, AJ and Stutz, AE and Tarling, CA and Withers, SG and Wolfler, H} }