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Mechanistic aspects of enzymatic carbohydrate epimerization

TitleMechanistic aspects of enzymatic carbohydrate epimerization
Publication TypeJournal Article
Year of Publication2002
AuthorsSamuel, J, Tanner, ME
JournalNatural Product Reports
Volume19
Pagination261-277
Date PublishedJun
Type of ArticleReview
ISBN Number0265-0568
Keywords2-EPIMERASE, ACETYLNEURAMINIC, ACID BIOSYNTHESIS, D-GLUCOSAMINE 2-EPIMERASE, D-MANNOHEPTOSE 6-EPIMERASE, GDP-L-FUCOSE, GLUCURONYL C-5 EPIMERASE, MANNURONAN C-5-EPIMERASE, N-ACETYLGLUCOSAMINE, RENIN-BINDING PROTEIN, SITE-DIRECTED MUTAGENESIS, UDP-GALACTOSE 4-EPIMERASE, VINELANDII
Abstract

Carbohydrate epimerases are enzymes that catalyze an inversion of stereochemistry at a stereogenic center in a sugar. This review focuses on the mechanistic strategies that are employed by this diverse family of enzymes, and is divided into the following sections: deprotonation/reprotonation, transient oxidation, cofactor independent, and mutarotation. The review is comprehensive up to Oct. 2001 and contains 216 references.

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