| Title | Direct monitoring of equilibrium protein folding-unfolding by atomic force microscopy: pushing the limit |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Xiao, A, Li, H |
| Journal | CHEMICAL COMMUNICATIONS |
| Volume | 55 |
| Pagination | 12920-12923 |
| Date Published | NOV 7 |
| ISSN | 1359-7345 |
| Abstract | We report the direct observation of equilibrium folding-unfolding dynamics of a mechanically labile, three helix bundle protein GA using a commercial atomic force microscope (AFM). Our study extends the capability of commercial AFMs towards studying protein unfolding/refolding at equilibrium as well as increasingly complex biomolecular systems in the context of biological function. |
| DOI | 10.1039/c9cc06293a |
