@article { ISI:000492378600003, title = {Direct monitoring of equilibrium protein folding-unfolding by atomic force microscopy: pushing the limit}, journal = {CHEMICAL COMMUNICATIONS}, volume = {55}, number = {86}, year = {2019}, month = {NOV 7}, pages = {12920-12923}, abstract = {We report the direct observation of equilibrium folding-unfolding dynamics of a mechanically labile, three helix bundle protein GA using a commercial atomic force microscope (AFM). Our study extends the capability of commercial AFMs towards studying protein unfolding/refolding at equilibrium as well as increasingly complex biomolecular systems in the context of biological function.}, issn = {1359-7345}, doi = {10.1039/c9cc06293a}, author = {Xiao, Adam and Li, Hongbin} }