| Title | Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Zoidl, M, Mueller, B, Torvisco, A, Tysoe, C, Benazza, M, Siriwardena, A, Withers, SG, Wrodnigg, TM |
| Journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| Volume | 24 |
| Pagination | 2777-2780 |
| Date Published | JUN 15 |
| ISSN | 0960-894X |
| Abstract | A new Staudinger/aza Wittig/Strecker multicomponent reaction sequence to C-1-cyano iminoalditols has been developed. When applied to 5-azidodeoxy-D-xylose and -D-glucose as substrates the method leads smoothly in good yield and with excellent stereoselectivity to respectively, 1,5-dideoxy-1,5-imino-D-idurono nitrile and 2,6-didesoxy-2,6-imino-D-glycero-D-ido-heptononitrile. (C) 2014 Published by Elsevier Ltd. |
| DOI | 10.1016/j.bmcl.2014.03.069 |
