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A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer

TitleA xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer
Publication TypeJournal Article
Year of Publication2003
AuthorsGloster, T, Williams, SJ, Tarling, CA, Roberts, S, Dupont, C, Jodoin, P, Shareck, F, Withers, SG, Davies, GJ
JournalCHEMICAL COMMUNICATIONS
Pagination944-945
ISSN1359-7345
Abstract

The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with ``reversed{''} protonation-states for nucleophile and acid-base.

DOI10.1039/b301829f