| Title | A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Gloster, T, Williams, SJ, Tarling, CA, Roberts, S, Dupont, C, Jodoin, P, Shareck, F, Withers, SG, Davies, GJ |
| Journal | CHEMICAL COMMUNICATIONS |
| Pagination | 944-945 |
| ISSN | 1359-7345 |
| Abstract | The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with ``reversed{''} protonation-states for nucleophile and acid-base. |
| DOI | 10.1039/b301829f |
