|Title||X-ray crystallographic and C-13 NMR investigations of the effects of electron-withdrawing groups on a series of pyrroles|
|Publication Type||Journal Article|
|Year of Publication||2000|
|Authors||Thompson, A, Gao, S, Modzelewska, G, Hughes, DS, Patrick, B, Dolphin, D|
|Type of Article||Article|
|Keywords||DERIVATIVES, NUCLEAR MAGNETIC-RESONANCE, THIOPHENES|
[GRAPHICS] A series of pyrroles substituted with various electron-withdrawing groups (EWGs) on the N atom have been synthesized and full characterization including X-ray crystal structures obtained, Analysis of C-13 chemical shifts and X-ray crystal structures reveals that a trend between decreased aromaticity and the strength of the EWG exists. Experimental results regarding alternative mechanisms of nucleophilic substitution reactions can thus be rationalized.
|URL||<Go to ISI>://000165301700015|