|Title||The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Rye, CS, Withers, SG|
|Date Published||FEB 25|
A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars. (C) 2004 Elsevier Ltd. All rights reserved.