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Synthesis and spectral studies of natural chlorins having antioxidative activity

TitleSynthesis and spectral studies of natural chlorins having antioxidative activity
Publication TypeJournal Article
Year of Publication1996
AuthorsMa, LF, Dolphin, D
JournalPure and Applied Chemistry
Volume68
Pagination765-769
Date PublishedMar
Type of ArticleProceedings Paper
ISBN Number0033-4545
KeywordsCOMPOUND, enol, RUDITAPES-PHILIPPINARUM
Abstract

Starting from pheophorbide a methyl ester (1), a degradation product of chlorophyll a, novel natural antioxidants of chlorophyll a related chlorins 3, 5(S), 5(R), 8(R), 9-13 have been synthesized in high yields. Key steps involve formation of 5(R) and 5(8) via a DBU-promoted asymmetric hydroxylation of 3, and regioselective periodate oxidations of 5 to 8(R) and 9.
URL<Go to ISI>://A1996UM99400059