|Title||Synthesis and biological evaluation of novel biotin-iminoalditol conjugates|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Pototschnig, G, De Csaky, CMorales, Burke, JRMontene, Schitter, G, Stuetz, AE, Tarling, CA, Withers, SG, Wrodnigg, TM|
|Journal||BIOORGANIC & MEDICINAL CHEMISTRY LETTERS|
|Date Published||JUL 15|
Biotin-iminosugar conjugates of different configuration such as D-gluco, D-galacto, L-ido as well as a furanoid representative in the D-manno configuration have been synthesised and exhibit powerful inhibition of beta-glucosidase from Agrobacterium sp. with K(i) values in the range of the respective parent compounds. Such molecular probes have potential for activity-based protein pro. ling taking advantage of the biotin-(strept)avidin interaction. (C) 2010 Elsevier Ltd. All rights reserved.