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Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

TitleStructure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis
Publication TypeJournal Article
Year of Publication2009
AuthorsOffen, WA, Zechel, DL, Withers, SG, Gilbert, HJ, Davies, GJ
JournalCHEMICAL COMMUNICATIONS
Pagination2484-2486
ISSN1359-7345
Abstract

The Michaelis complex of the beta-mannosidase Man2A shows distortion to a S-1(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.

DOI10.1039/b902240f