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A sequential C-N, C-C bond-forming reaction: Direct synthesis of alpha-amino acids from terminal alkynes

TitleA sequential C-N, C-C bond-forming reaction: Direct synthesis of alpha-amino acids from terminal alkynes
Publication TypeJournal Article
Year of Publication2006
AuthorsLee, AV, Schafer, LL
JournalSynlett
Pagination2973-2976
Date PublishedNov
ISBN Number0936-5214
Abstract

Catalytic hydroamination is combined with the Strecker reaction to yield a one-pot synthesis of alpha-cyanoamines from terminal alkynes. This methodology is further applied to the synthesis of alpha-amino acids and alpha-amino esters.

URL<Go to ISI>://000243619600017