Congratulations to the Sammis Lab group!
The Sammis Lab groups most recent paper, Single-Electron/Pericyclic Cascade for the Synthesis of Dienes, has been featured in Angewandte Chemie International Edition. According to their Editor, it is being described as “hot paper” status.
—
Abstract
The highly efficient and diastereoselective synthesis of E dienes has been accomplished through radical cyclization of bromoallyl hydrazones. This methodology has been further extended to generate these products through a one-pot condensation/radical cyclization/cycloreversion cascade from simple aldehyde starting materials in high yields (>75 %) and high diastereoselectivities (>95:5). Mechanistic investigations suggest that the cascade reaction proceeds through a cyclic diazene intermediate prior to the cycloreversion.
Read more