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Ruthenium(II) acetylacetonato-sulfoxide complexes

TitleRuthenium(II) acetylacetonato-sulfoxide complexes
Publication TypeJournal Article
Year of Publication2003
AuthorsWu, A, Kennedy, DC, Patrick, BO, James, BR
JournalInorganic Chemistry Communications
Volume6
Pagination996-1000
Date PublishedAug
Type of ArticleArticle
ISBN Number1387-7003
Keywords2D NMR spectroscopy, acetylacetonato, ANTITUMOR-ACTIVITY, CANCER, CHEMISTRY, COLORIMETRIC ASSAY, COORDINATION, INVITRO, PRECURSOR, ruthenium, STRUCTURAL-CHARACTERIZATION, sulfoxides, TUMOR CELL-LINES
Abstract

The water-soluble Ru-II acetylacetonato-sulfoxide complexes, cis-Ru(acac)(2)(DMSO)(2) (1) and Ru(acac)(2)(meso-BESE) (2), were synthesized (BESE = 1,2-bis(ethylsulfinyl)ethane = EtS(O)(CH2)(2)S(O)Et). Both complexes were characterized by H-1 and C-13{H-1} NMR, UV-Vis, and IR spectroscopies, as well as MS, elemental analysis, solution conductivity, and cyclic voltammetry, while the molecular structure of 2 was determined also by X-ray crystallography. All sulfoxide ligands are S-bonded. The complexes were tested against human breast cancer cells (MDA-MB-435S) using an in vitro MTT assay, a colorimetric determination of cell viability; IC50 values of >2000 and 1500 +/- 100 muM were determined for 1 and 2, respectively, while cisplatin exhibits an IC50 value of 30 +/- 5 muM. (C) 2003 Elsevier Science B.V. All rights reserved.

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