IDG seminars will be held in D300 and also available on zoom this term. Please contact for zoom details.
The catalytic functionalization of the α C-H bond of amines has become a powerful strategy for synthesizing nitrogen-containing compounds. This presentation will discuss progress toward catalytic hydroaminoalkylation of alkynes and dienes, where the α C-H bond of an amine is added across a π bond of the unsaturated substrate in a 100 % atom-economical manner. Mechanistic insights of these reactions will be discussed based on the isolation and reactivity assessment of catalytic intermediates. In addition, a cross-dehydrogenative coupling reaction between nitrogen-containing heterocycles and amines will be presented.
In these reactions, the expanded coordination number at zirconium plays a critical role in enabling challenging reaction steps as supported experimentally and by DFT calculations.