| Title | Piperazate-guided isolation of caveamides A and B, cyclohexenylalanine-containing nonribosomal peptides from a cave actinomycete |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Hagar, M, Morgan, KD, Stumpf, SD, Tsingos, M, Banuelos, CA, Sadar, MD, Blodgett, JAV, Andersen, RJ, Ryan, KS |
| Journal | Org. Lett. |
| Volume | 26 |
| Pagination | 4127–4131 |
| Abstract | Hybrid genome-mining/15N-NMR was used to target compounds containing piperazate (Piz) residues, leading to the discovery of caveamides A (1) and B (2) from Streptomyces sp. strain BE230, isolated from New Rankin Cave (Missouri). Caveamides are highly dynamic molecules containing an unprecedented $\beta$-ketoamide polyketide fragment, two Piz residues, and a new N-methyl-cyclohexenylalanine residue. Caveamide B (2) exhibited nanomolar cytotoxicity against several cancer cell lines and nanomolar antimicrobial activity against MRSA and E. coli. |
