| Title | OGA inhibition by GlcNAc-selenazoline |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Kim, EJu, Love, DC, Darout, E, Abdo, M, Rempel, B, Withers, SG, Rablen, PR, Hanover, JA, Knapp, S |
| Journal | BIOORGANIC & MEDICINAL CHEMISTRY |
| Volume | 18 |
| Pagination | 7058-7064 |
| Date Published | OCT 1 |
| ISSN | 0968-0896 |
| Abstract | The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes. (C) 2010 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.bmc.2010.08.010 |
