Research & Faculty

Default Header Image

A fluorescent probe for GM1 gangliosidosis related beta-galactosidase: N-(Dansylamino) hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol

TitleA fluorescent probe for GM1 gangliosidosis related beta-galactosidase: N-(Dansylamino) hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol
Publication TypeJournal Article
Year of Publication2011
AuthorsFroehlich, RFG, Fantur, K, Furneaux, RH, Paschke, E, Stuetz, AE, Wicki, J, Withers, SG, Wrodnigg, TM
JournalBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume21
Pagination6872-6875
Date PublishedNOV 15
ISSN0960-894X
Abstract

N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactit ol, a strong competitive inhibitor of beta-galactosidase, enhances residual beta-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant beta-gal as well as aberrant GM1 gangliosides by live cell imaging. (C) 2011 Elsevier Ltd. All rights reserved.

DOI10.1016/j.bmcl.2011.09.012