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Escherichia coli glucuronylsynthase: An engineered enzyme for the synthesis of beta-glucuronides

TitleEscherichia coli glucuronylsynthase: An engineered enzyme for the synthesis of beta-glucuronides
Publication TypeJournal Article
Year of Publication2008
AuthorsWilkinson, SM, Liew, CW, Mackay, JP, Salleh, HM, Withers, SG, McLeod, MD
JournalORGANIC LETTERS
Volume10
Pagination1585-1588
Date PublishedAPR 17
ISSN1523-7060
Abstract

The glycosynthase derived from E coli beta-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of 6-glucuronides under mild conditions.

DOI10.1021/ol8002767