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Covalent inhibitors of glycosidases and their applications in biochemistry and biology

TitleCovalent inhibitors of glycosidases and their applications in biochemistry and biology
Publication TypeJournal Article
Year of Publication2008
AuthorsRempel, BP, Withers, SG
JournalGLYCOBIOLOGY
Volume18
Pagination570-586
Date PublishedAUG
ISSN0959-6658
Abstract

Glycoside hydrolases are important enzymes in a number of essential biological processes. Irreversible inhibitors of this class of enzyme have attracted interest as probes of both structure and function. In this review we discuss some of the compounds used to covalently modify glycosidases, their use in residue identification, structural and mechanistic investigations, and finally their applications, both in vitro and in vivo, to complex biological systems.

DOI10.1093/glycob/cwn041