| Title | 2-Acetamino-1,2-dideoxynojirimycin-lysine hybrids as hexosaminidase inhibitors |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Steiner, AJ, Schitter, G, Stuetz, AE, Wrodnigg, TM, Tarling, CA, Withers, SG, Mahuran, DJ, Tropak, MB |
| Journal | TETRAHEDRON-ASYMMETRY |
| Volume | 20 |
| Pagination | 832-835 |
| Date Published | MAY 7 |
| ISSN | 0957-4166 |
| Abstract | Cyclisation by double reductive amination of 2-acetamino-2-deoxy-D-xylo-hexos-5-ulose with N-2 protected L-lysine derivatives provided 2-acetamino-1,2-dideoxynojirimycin derivatives without any observable epimer formation at C-5. Modifications on the lysine moiety gave access to lipophilic derivatives that exhibited improved hexosaminidase inhibitory activities. (C) 2009 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2009.02.015 |
