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Synthesis and biological evaluation of novel biotin-iminoalditol conjugates

TitleSynthesis and biological evaluation of novel biotin-iminoalditol conjugates
Publication TypeJournal Article
Year of Publication2010
AuthorsPototschnig, G, De Csaky, CMorales, Burke, JRMontene, Schitter, G, Stuetz, AE, Tarling, CA, Withers, SG, Wrodnigg, TM
JournalBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume20
Pagination4077-4079
Date PublishedJUL 15
ISSN0960-894X
Abstract

Biotin-iminosugar conjugates of different configuration such as D-gluco, D-galacto, L-ido as well as a furanoid representative in the D-manno configuration have been synthesised and exhibit powerful inhibition of beta-glucosidase from Agrobacterium sp. with K(i) values in the range of the respective parent compounds. Such molecular probes have potential for activity-based protein pro. ling taking advantage of the biotin-(strept)avidin interaction. (C) 2010 Elsevier Ltd. All rights reserved.

DOI10.1016/j.bmcl.2010.05.084