| Title | Synthesis and biological evaluation of novel biotin-iminoalditol conjugates |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Pototschnig, G, De Csaky, CMorales, Burke, JRMontene, Schitter, G, Stuetz, AE, Tarling, CA, Withers, SG, Wrodnigg, TM |
| Journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| Volume | 20 |
| Pagination | 4077-4079 |
| Date Published | JUL 15 |
| ISSN | 0960-894X |
| Abstract | Biotin-iminosugar conjugates of different configuration such as D-gluco, D-galacto, L-ido as well as a furanoid representative in the D-manno configuration have been synthesised and exhibit powerful inhibition of beta-glucosidase from Agrobacterium sp. with K(i) values in the range of the respective parent compounds. Such molecular probes have potential for activity-based protein pro. ling taking advantage of the biotin-(strept)avidin interaction. (C) 2010 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.bmcl.2010.05.084 |
