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Alternative donor substrates for inverting and retaining glycosyltransferases

TitleAlternative donor substrates for inverting and retaining glycosyltransferases
Publication TypeJournal Article
Year of Publication2007
AuthorsLairson, LL, Wakarchuk, WW, Withers, SG
JournalCHEMICAL COMMUNICATIONS
Pagination365-367
ISSN1359-7345
Abstract

By the use of glycosyl donors containing aromatic leaving groups linked with opposite anomeric configurations compared to those of the natural donor substrates, an inverting (Cst II) and a retaining (LgtC) glycosyltransferase were found to catalyse glycosylation reactions of natural acceptor substrates in the presence of the corresponding nucleotide.

DOI10.1039/b614636h