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Thioglycosynthases: double mutant glycosidases that serve as scaffolds for thioglycoside synthesis

TitleThioglycosynthases: double mutant glycosidases that serve as scaffolds for thioglycoside synthesis
Publication TypeJournal Article
Year of Publication2004
AuthorsJahn, M, Chen, HM, Mullegger, J, Marles, J, WARREN, RAJ, Withers, SG
JournalCHEMICAL COMMUNICATIONS
Pagination274-275
Date PublishedFEB 7
ISSN1359-7345
Abstract

A double mutant, retaining glycosidase that lacks both the catalytic nucleophile and the catalytic acid/base residues efficiently catalyzes thioglycoside formation from a glycosyl fluoride donor and thiosugar acceptors.

DOI10.1039/b313155f