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The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases

TitleThe synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases
Publication TypeJournal Article
Year of Publication2004
AuthorsRye, CS, Withers, SG
JournalCARBOHYDRATE RESEARCH
Volume339
Pagination699-703
Date PublishedFEB 25
ISSN0008-6215
Abstract

A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars. (C) 2004 Elsevier Ltd. All rights reserved.

DOI10.1016/j.carres.2003.12.011