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Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics

TitleFluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics
Publication TypeJournal Article
Year of Publication2006
AuthorsLundt, I, Steiner, AJ, Stutz, AE, Tarling, CA, Ully, S, Withers, SG, Wrodnigg, TM
JournalBIOORGANIC & MEDICINAL CHEMISTRY
Volume14
Pagination1737-1742
Date PublishedMAR 15
ISSN0968-0896
Abstract

1,5-Dideoxy-1,5-imino-D-glucitol,the corresponding D-manno and L-ido epimers as well as the powerful P-glucosidase inhibitor isofagomine were N-alkylated with di-, tri-, as well as tetraethylene glycol derived straight chain spacer arms by a set of simple standard procedures. The terminal functional groups of the spacer arms, primary amines, were employed to introduce fluorescent dansyl moieties. Resulting derivatives showed glycosidase inhibitory activities comparable to those of the parent compounds'. (c) 2005 Elsevier Ltd. All rights reserved.

DOI10.1016/j.bmc.2005.10.021