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Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

TitleAtomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A
Publication TypeJournal Article
Year of Publication2004
AuthorsGloster, TM, Williams, SJ, Roberts, S, Tarling, CA, Wicki, J, Withers, SG, Davies, GJ
JournalCHEMICAL COMMUNICATIONS
Pagination1794-1795
ISSN1359-7345
Abstract

The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

DOI10.1039/b405152a