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Detailed structural analysis of glycosidase/inhibitor interactions: Complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars

TitleDetailed structural analysis of glycosidase/inhibitor interactions: Complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars
Publication TypeJournal Article
Year of Publication2000
AuthorsNotenboom, V, Williams, SJ, HOOS, R, Withers, SG, ROSE, DR
JournalBIOCHEMISTRY
Volume39
Pagination11553-11563
Date PublishedSEP 26
ISSN0006-2960
Abstract

{Detailed insights into the mode of binding of a series of tight-binding aza-sugar glycosidase inhibitors of two fundamentally different classes are described through X-ray crystallographic studies of complexes with the retaining family 10 xylanase Cex from Cellulomonas fimi. Complexes with xylobiosederived aza-sugar inhibitors of the substituted ``amidine{''} class (xylobio-imidazole

DOI10.1021/bi0010625